Methylamine hydrochloride

Base Information

• Chemical Name: Methylamine hydrochloride
• CAS No.: 593-51-1
• Molecular Formula: CH6ClN
• Molecular Weight: 67.5183
• Hs Code.: 29211190
• European Community (EC) Number: 209-795-0
• NSC Number: 89685
• UNII: M439EX322K
• Wikipedia: Methylammonium_chloride
• Wikidata: Q27126640
• Mol file: 593-51-1.mol

Synonyms:aminomethane;methylamine;methylamine bisulfite;methylamine hydride;methylamine hydrobromide;methylamine hydrochloride;methylamine hydrochloride, 14C-labeled;methylamine hydrofluoride;methylamine hydrogen cyanide;methylamine hydroiodide;methylamine ion (1-);methylamine nitrate;methylamine perchlorate;methylamine sulfate (1:1);methylamine sulfate (2:1);methylamine, 13C-labeled;methylamine, 14C-labeled;methylamine, 15N-labeled;methylamine, cesium salt;methylamine, monopotassium salt;methylamine, monosodium salt;methylammonium;methylammonium ion;monomethylamine;monomethylammonium ion

Chemical Property of Methylamine hydrochloride

Chemical Property:

• Appearance/Colour: white to light tan solid
• Vapor Pressure: 3970mmHg at 25°C
• Melting Point: 231-233 °C(lit.)
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 38.2 °C at 760 mmHg
• Flash Point: 225-230°C/15mm
• PSA: 26.02000
• Density: 0.8306 (rough estimate)
• LogP: 1.07720
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Solubility.: soluble
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 67.0188769
• Heavy Atom Count: 3
• Complexity: 2

Purity/Quality:

99% ^*data from raw suppliers

Methylamine Hydrochloride >98.0%(N) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CN.Cl
• Uses: Methylamine is used as a building block for the synthesis of other organic compounds. It is on the DEA watchlist for chemical precursors because of clandestine use in manufacture of the drug MDMA (ecstasy) and methamphetamine.The HCl salt is in the form of white deliquescent crystals, and is frequently substitutable for the aq. soln. in many synthesis preparations. Methylamines are used directly as catalysts or as raw materials to produce other compounds with catalytic activity. Fuel additives are used to improve engine performance in a variety of ways. Trimethylamine is used to make paper chemicals. The manufacture of intermediates to make pharmaceuticals is one of the most diverse uses of methylamines.

Technology Process of Methylamine hydrochloride

There total 92 articles about Methylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-Nitroso-N-methylmethoxymethylamine (39885-14-8) → methylamine hydrochloride (593-51-1)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Heating;

DOI:10.1021/jo00162a019

Reference yield: 96.0%

(E)-2-Chloro-3-hydroxy-but-2-enoic acid methyl ester (115584-91-3,935744-33-5) + diethylamine (109-89-7) → methylamine hydrochloride (593-51-1) + (E)-2-Chloro-3-hydroxy-but-2-enoic acid methyl ester; compound with diethyl-amine

Guidance literature:

In diethyl ether; at -40 ℃; for 1h;

DOI:10.1007/BF01557519

Reference yield: 95.0%

bis(trifluoromethyl)chlorophosphine (650-52-2) → methylamino-bis-trifluoromethyl-phosphine (431-98-1) + methylamine hydrochloride (593-51-1)

Guidance literature:

With CH₃NH₂; In gaseous matrix; 0°C;

DOI:10.1039/JR9580000512

upstream raw materials:

methanol

formaldehyd

trimethylamine hydrochloride

ephedrine hydrochloride

Downstream raw materials:

5-methyl-2-<(methylamino)methyl>thiophene

N-methyl(1-methyl-1H-pyrrol-2-yl)methylanamine

betahistine

4-hydroxy-4-(4-methylphenyl)-1-methylpiperidine

Refernces

• 1、 Qian, Feng,Gong, Jue,Hu, Mingyu,Ge, Chunyu,Padture, Nitin P.,Zhou, Yuanyuan,Feng, Jing. "P-P orbital interaction: via magnesium isovalent doping enhances optoelectronic properties of halide perovskites". . p. 15639 - 15642. Retrieved 2020.
• 2、 Xu, Qiang,Shao, Wenyi,Li, Yang,Zhang, Hang,Ouyang, Xiao,Zhang, Xinlei,Nie, Jing,Ouyang, Xiaoping,Liu, Bo. "Visual clarity methylammonium lead trichloride perovskite single crystals for X and gamma rays protection". . . Retrieved 2019.
• 3、 Stammler. "". . p. 2203,2210. Retrieved 1967.
• 4、 Aston, J. G.,Ziemer, C. W.. "". . p. 1405 - 1413. Retrieved 1946.
• 5、 Guo, Chenjun,Zhang, Fangcao,Yu, Chong,Luo, Yunjie. "Reduction of Amides to Amines with Pinacolborane Catalyzed by Heterogeneous Lanthanum Catalyst La(CH2C6H4NMe2- o)3@SBA-15". supporting information. p. 13122 - 13135. Retrieved 2021/08/31.