ETHYL 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE-3-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE-3-CARBOXYLATE
• CAS No.: 24237-39-6
• Molecular Formula: C11H16 N2 O2 S
• Molecular Weight: 240.326
• Hs Code.: 2934999090
• Mol file: 24237-39-6.mol

Synonyms:NSC 157359

Chemical Property of ETHYL 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE-3-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 7.98E-07mmHg at 25°C
• Melting Point: 103-105oC
• Boiling Point: 406.7°Cat760mmHg
• PKA: 7.24±0.20(Predicted)
• Flash Point: 199.8°C
• PSA: 83.80000
• Density: 1.242g/cm³
• LogP: 2.01400

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE-3-CARBOXYLATE

There total 2 articles about ETHYL 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-Methyl-4-piperidone (1445-73-4) + ethyl 2-cyanoacetate (105-56-6) → 2-amino-3-carboethoxy-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine (24237-39-6)

Guidance literature:

With morpholine; sulfur; In ethanol; at 60 ℃;

DOI:10.1016/j.bmcl.2005.04.077

Reference yield:

→ 2-amino-3-carboethoxy-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine (24237-39-6)

Guidance literature:

With sulfur; triethylamine; In ethanol; for 12h; Reflux;

Reference yield: 80.0%

2-amino-3-carboethoxy-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine (24237-39-6) + 3-methoxyphenyl isothiocyanate (3125-64-2) → ethyl 2-(3-(3-methoxyphenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

Guidance literature:

With pyridine; at 100 ℃; for 0.0333333h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.bioorg.2020.104509

upstream raw materials:

1-Methyl-4-piperidone

ethyl 2-cyanoacetate

Downstream raw materials:

ethyl 6-methyl-2-(3-phenylthioureido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

3-(4-chlorophenyl)-7-methyl-2-thioxo-2,3,5,6,7,8-hexahydro-1H-pyrido[3',4':5,4]thieno[2,3-d]pyrimidin-4-one

ethyl 2-(3-(4-chlorophenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate