ethyl 2-(3-(4-chlorophenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 2-(3-(4-chlorophenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
• CAS No.: 189067-64-9
• Molecular Formula: C₁₈H₂₀ClN₃O₂S₂
• Molecular Weight: 409.961

Synonyms:ethyl 2-(3-(4-chlorophenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

Chemical Property of ethyl 2-(3-(4-chlorophenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

Chemical Property:

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Technology Process of ethyl 2-(3-(4-chlorophenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

There total 3 articles about ethyl 2-(3-(4-chlorophenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-amino-3-carboethoxy-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine (24237-39-6) + 4-Chlorophenyl isothiocyanate (2131-55-7) → ethyl 2-(3-(4-chlorophenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (189067-64-9)

Guidance literature:

for 0.0125h; microwave irradiation;

DOI:10.3390/11070498

Reference yield:

1-Methyl-4-piperidone (1445-73-4) → ethyl 2-(3-(4-chlorophenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (189067-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur; diethylamine / methanol / 0.07 h / 100 °C / Microwave irradiation

2: pyridine / 0.03 h / 100 °C / Microwave irradiation; Sealed tube

With pyridine; sulfur; diethylamine; In methanol;

DOI:10.1016/j.bioorg.2020.104509

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → ethyl 2-(3-(4-chlorophenyl)thioureido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (189067-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur; diethylamine / methanol / 0.07 h / 100 °C / Microwave irradiation

2: pyridine / 0.03 h / 100 °C / Microwave irradiation; Sealed tube

With pyridine; sulfur; diethylamine; In methanol;

DOI:10.1016/j.bioorg.2020.104509

upstream raw materials:

2-amino-3-carboethoxy-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

4-Chlorophenyl isothiocyanate

1-Methyl-4-piperidone

ethyl 2-cyanoacetate

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