1,1'-Biphenyl, 3,3',4,4',5,5'-hexafluoro-

Base Information

• Chemical Name: 1,1'-Biphenyl, 3,3',4,4',5,5'-hexafluoro-
• CAS No.: 505058-38-8
• Molecular Formula: C12H4F6
• Molecular Weight: 262.15100
• Mol file: 505058-38-8.mol

Synonyms:1,1'-Biphenyl,3,3',4,4',5,5'-hexafluoro;

Chemical Property of 1,1'-Biphenyl, 3,3',4,4',5,5'-hexafluoro-

Chemical Property:

• PSA: 0.00000
• LogP: 4.18820

Purity/Quality:

99% ^*data from raw suppliers

3,3’,4,4’,5,5’-Hexafluoro-1,1’-biphenyl ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1'-Biphenyl, 3,3',4,4',5,5'-hexafluoro-

There total 18 articles about 1,1'-Biphenyl, 3,3',4,4',5,5'-hexafluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1,3,5-trifluorophenylzinc pivalate magnesium chloride pivalate lithium chloride + 3,4,5-trifluoro-1-bromobenzene (138526-69-9) → 2,3′,4,4′,5′,6-hexafluoro-1,1′-biphenyl + 3,3′,4,4′,5,5′-hexafluoro-1,1′-biphenyl (505058-38-8)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl(2’,4’,6’-triisopropyl-[ 1,1’-bi-phenyl]-2-yl)phosphane; In tetrahydrofuran; at 55 ℃; for 24h;

DOI:10.1055/a-1647-6973

Reference yield: 83.0%

3,4,5-trifluoro-1-bromobenzene (138526-69-9) + 3,4,5-trifluorophenylboronic acid (143418-49-9) → 3,3′,4,4′,5,5′-hexafluoro-1,1′-biphenyl (505058-38-8)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; CyJohnPhos; In tetrahydrofuran; water; toluene; at 95 ℃; for 60h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.7b02267

Reference yield: 82.0%

cyclopent-3-enyl bromide (1781-66-4) + 3,4,5-trifluoro-1-bromobenzene (138526-69-9) → bi-3-cyclopenten-1-yl + 3,3′,4,4′,5,5′-hexafluoro-1,1′-biphenyl (505058-38-8) + 4-(3,4,5-trifluorophenyl)cyclopentene (599204-63-4)

Guidance literature:

cyclopent-3-enyl bromide; With magnesium; In diethyl ether;

3,4,5-trifluoro-1-bromobenzene; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In diethyl ether; at 20 ℃; for 12h; Further stages.;

DOI:10.1002/ejoc.200300448

upstream raw materials:

4-fluorobenzenediazonium tetrafluoroborate

4-fluoro-1-iodobenzene

cyclopent-3-enyl bromide

3,4,5-trifluoro-1-bromobenzene