138526-69-9

Basic information

• Product Name: 5-Bromo-1,2,3-trifluorobenzene
• Synonyms: 5-BROMO-1,2,3-TRIFLUOROBENZENE;3,4,5-TRIFLUOROBROMOBENZENE;1-BROMO-3,4,5-TRIFLUOROBENZENE;1,2,3-TRIFLUORO-5-BROMOBENZENE;BENZENE, 5-BROMO-1,2,3-TRIFLUORO-;1-Bromo-3,4,5-trifluoribenzene;3,4,5-Trifluoro-1-bromobenzene;3,4,5-Ttrifluorobromobenzene
• CAS NO: 138526-69-9
• Molecular Formula: C₆H₂BrF₃
• Molecular Weight: 210.98
• EINECS: 418-480-9
• Product Categories: Other fluorin-contained compounds;Fluorobenzene;Aromatic Hydrocarbons (substituted) & Derivatives;Miscellaneous;Benzenes;Aryl;Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series
• Mol File: 138526-69-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: <-20°C
• Boiling Point: 47-49 °C60 mm Hg(lit.)
• Flash Point: 113 °F
• Appearance: Colorless to yellowish liquid
• Density: 1.767 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.6mmHg at 25°C
• Refractive Index: n20/D 1.482(lit.)
• Storage Temp.: Flammables area
• Solubility: 0.130g/l
• Water Solubility: insoluble
• BRN: 7249191
• CAS DataBase Reference: 5-Bromo-1,2,3-trifluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-1,2,3-trifluorobenzene(138526-69-9)
• EPA Substance Registry System: 5-Bromo-1,2,3-trifluorobenzene(138526-69-9)

Safety Data

• Hazard Codes: Xn,N,Xi,F
• Statements: 10-38-40-41-51/53-36/37/38
• Safety Statements: 23-26-36/37/39-61-36-16
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 2
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 138526-69-9(Hazardous Substances Data)

Usage

Chemical Properties

Clear slightly yellow liquid

Uses

Different sources of media describe the Uses of 138526-69-9 differently. You can refer to the following data:
1. 5-Bromo-1,2,3-trifluorobenzene was used in flow preparation of 4,4,5,5-tetramethyl-2-(3,4,5-trifluorophenyl)-1,3,2-dioxaborolane.
2. Intermediates of Liquid Crystals

Flammability and Explosibility

Flammable

InChI:InChI:1S/C6H2BrF3/c7-3-1-4(8)6(10)5(9)2-3/h1-2H

Upstream product

• 2268-05-5 1,3-dichloro-2-fluorobenzene 
• 2729-34-2 3,5-dichloro-4-fluorophenylamine 
• 3107-19-5 3,5-dichloro-4-fluoro-nitrobenzene 
• 20098-48-0 3,4,5-trichloronitrobenzen 
• 122375-82-0 2-bromo-4,5,6-trifluoroaniline 
• 393-79-3 1,3-dichloro-2-fluoro-4-nitrobenzene 
• 34628-01-8 1,2,3-tribromo-4,5,6-trifluoro-benzene 
• 17299-95-5 1,5-dibromo-2,3,4-trifluorobenzene 
• 17299-94-4 1,2-dibromo-3,4,5-trifluorobenzene 
• 163733-96-8 3,4,5-trifluoro aniline 
• 176317-02-5 1-bromo-2,3,4-trifluorobenzene 
• 1489-53-8 1,2,3-trifluorobenzene 
• 530145-55-2 2,3,4-trifluoro-1,5-phenylenebis(triethylsilane) 
• 530145-56-3 (5-bromo-2,3,4-trifluorophenyl)triethylsilane 

Downstream Products

• 409359-34-8 5-cyano-2-methoxy-N-[2-(3',4',5'-trifluoro-3-methoxymethoxybiphenyl-4-yl)ethyl]benzenesulfonamide 
• 156006-28-9 3,4,5-trifluorophenylmagnesium bromide 
• 326795-64-6 2-propyl-7-(3,4,5-trifluorophenyl)-9,10-dihydrophenanthrene 
• 160148-05-0 4-(3',4',5'-trifluorophenyl)cyclohexanone 
• 204654-92-2 3,4-difluoro-5-ethoxybromobenzene 
• 1129540-95-9 4-(5-bromo-2,3-difluorophenyl)morpholine 
• 827614-70-0 2-(3,4,5-trifluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1338809-70-3 C₁₂H₆BF₃O₂ 
• 1372535-62-0 1-bromo-3,4,5-tridodecylsulfanylbenzene 

Relevant articles and documents

Green synthesis method of 3,4,5-trifluorobromobenzene

The invention discloses a green synthesis method of 3,4,5-trifluorobromobenzene. The green synthesis method comprises the following steps: adding 2,3,4-trifluoroaniline and water into a reactor, adding hydrobromic acid and hydrogen peroxide, and carrying out a hybrid reaction to obtain 2,3,4-trifluoro-6-bromoaniline after the reaction is ended; slowly adding a sulfuric acid solution of nitroso sulfuric acid into the prepared 2,3,4-trifluoro-6-bromoaniline, and carrying out a diazotization reaction to obtain a diazonium salt solution; and adding sodium hypophosphite and porous material-loaded copper oxide into the prepared diazonium salt solution as catalysts, conducting reacting, and sequentially carrying out distillation, alkali washing, water washing and reduced-pressure rectification on reaction liquid after the reaction is finished so as to obtain a target product. According to the method, nitrososulfuric acid replaces sodium nitrite to serve as a diazotization reagent, so no high-salt wastewater is discharged, production cost is reduced, and the method is more environmentally friendly; and hydrobromic acid serves as a bromine source, and hydrogen peroxide is added, so the utilization rate of bromine atoms is high, the adding amount of hydrobromic acid is reduced, and the amount of three wastes generated in implementation of the method is remarkably reduced.

Preparation method of 3,4,5-trifluorobromobenzene

The invention belongs to the technical field of fine chemicals, and in particular relates to a preparation method of 3,4,5-trifluorobromobenzene. The method comprises the following steps: firstly, dissolving 1,2,3-trifluoro-benzene in an organic solvent; then adding a sodium bromide aqueous solution containing a buffer solution; dropwise adding sodium hypochlorite to react for bromination; desolventizing an organic phase to obtain a 3,4,5-trifluorobromobenzene coarse product; and carrying out melt crystallization on the coarse product to obtain 3,4,5-trifluorobromobenzene. The preparation method provided by the invention is simple, the product yield reaches over 94%, the product yield is high, and the content of the prepared 3,4,5-trifluorobromobenzene reaches over 99.5%, and the preparation process is mild, efficient, environment-friendly, safe and reliable.

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.