6-methoxybenzofuran-2-carboxylic Acid

Base Information

• Chemical Name: 6-methoxybenzofuran-2-carboxylic Acid
• CAS No.: 50551-61-6
• Molecular Formula: C10H8O4
• Molecular Weight: 192.171
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID40358835
• Nikkaji Number: J3.081.498C
• Wikidata: Q82139706
• ChEMBL ID: CHEMBL4799101
• Mol file: 50551-61-6.mol

Synonyms:6-methoxybenzofuran-2-carboxylic Acid;50551-61-6;6-methoxy-1-benzofuran-2-carboxylic acid;6-methoxy-benzofuran-2-carboxylic acid;SCHEMBL178096;CHEMBL4799101;DTXSID40358835;6-methoxybenzofuran-2-carboxylicAcid;STK317989;6-methoxy-2-benzofurancarboxylic acid;AKOS000103490;AS-44010;BP-20306;CS-0062580;FT-0755785;EN300-100670

Chemical Property of 6-methoxybenzofuran-2-carboxylic Acid

Chemical Property:

• PSA: 59.67000
• LogP: 2.13960
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 192.04225873
• Heavy Atom Count: 14
• Complexity: 228

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Methoxybenzofuran-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C=C(O2)C(=O)O
• Uses: 6-Methoxybenzofuran-2-carboxylic acid

Technology Process of 6-methoxybenzofuran-2-carboxylic Acid

There total 15 articles about 6-methoxybenzofuran-2-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-bromo-7-methoxy-2H-chromen-2-one (72167-80-7) → 6-methoxybenzofuran-2-carboxylic acid (50551-61-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 4h;

DOI:10.3390/70300353

Reference yield: 91.0%

ethyl 6-methoxybenzo[b]furan-2-carboxylate (50551-57-0) → 6-methoxybenzofuran-2-carboxylic acid (50551-61-6)

Guidance literature:

ethyl 6-methoxybenzo[b]furan-2-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield: 91.0%

6-methoxy-2-benzofurancarboxylic acid methyl ester (55364-67-5) → 6-methoxybenzofuran-2-carboxylic acid (50551-61-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

upstream raw materials:

3-bromo-7-methoxy-2H-chromen-2-one

ethyl 6-methoxybenzo[b]furan-2-carboxylate

2-Hydroxy-4-methoxybenzaldehyde

Diethyl 2-bromomalonate

Downstream raw materials:

6-methoxy-2-benzofurancarboxylic acid methyl ester

(6-methoxy-1-benzofuran-2-yl)boronic acid

1-ethyl-2-(6-methoxybenzofuran-2-yl)-1H-imidazole hydrochloride

(2-Hydroxy-4-methoxy-phenyl)-(6-methoxy-benzofuran-2-yl)-methanone

Refernces

• 1、 Guo, Hui-Fang,Jin, Jie,Li, Zhuo-rong,Liu, Zong-ying,Xie, Zhuo-song,Xue, Si-tu,Yi, Hong,Zhang, Lei. "Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties". . . Retrieved 2020/06/01.
• 2、 Cao, Zhi-Ling,Liu, Shu-Hao,Liu, Wei-Wei,Liu, Xiu-Jian,Ren, Shu-Ting,Shi, Da-Hua,Wang, Lei,Wang, You-Xian,Wu, Yu-Ran. "Synthesis and AChE inhibitory activity of N-glycosyl benzofuran derivatives". . p. 162 - 166. Retrieved 2020/01/28.