Ethyl 6-methoxybenzofuran-2-carboxylate

Base Information

• Chemical Name: Ethyl 6-methoxybenzofuran-2-carboxylate
• CAS No.: 50551-57-0
• Molecular Formula: C₁₂H₁₂O₄
• Molecular Weight: 220.225
• Hs Code.: 2932999099
• ChEMBL ID: CHEMBL3415232
• DSSTox Substance ID: DTXSID60474122
• Wikidata: Q82303925
• Mol file: 50551-57-0.mol

Synonyms:Ethyl 6-methoxybenzofuran-2-carboxylate;50551-57-0;ethyl 6-methoxy-1-benzofuran-2-carboxylate;MFCD14279719;6-Methoxycumarilsaeureethylester;SCHEMBL177458;2-Benzofurancarboxylic acid, 6-methoxy-, ethyl ester;CHEMBL3415232;DTXSID60474122;VBJGXQIHVLKHCT-UHFFFAOYSA-N;AKOS003407274;Ethyl6-methoxybenzofuran-2-carboxylate;ethyl-6-methoxybenzofuran-2-carboxylate;BS-16940;SY045675;CS-0137483;A918385

Chemical Property of Ethyl 6-methoxybenzofuran-2-carboxylate

Chemical Property:

• Melting Point: 87 °C
• Boiling Point: 316.2±22.0 °C(Predicted)
• PSA: 48.67000
• Density: 1.192±0.06 g/cm3(Predicted)
• LogP: 2.61810
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 220.07355886
• Heavy Atom Count: 16
• Complexity: 253

Purity/Quality:

97% ^*data from raw suppliers

Ethyl6-methoxybenzofuran-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC2=C(O1)C=C(C=C2)OC

Technology Process of Ethyl 6-methoxybenzofuran-2-carboxylate

There total 8 articles about Ethyl 6-methoxybenzofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + chloroacetic acid ethyl ester (105-39-5) → ethyl 6-methoxybenzo[b]furan-2-carboxylate (50551-57-0)

Guidance literature:

With aluminum oxide; 3-ethyl-1-methyl-1H-imidazol-3-ium bromide; at 80 ℃; for 0.666667h; Ionic liquid;

DOI:10.1016/j.cclet.2010.06.038

Reference yield: 80.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + ethyl bromoacetate (105-36-2) → ethyl 6-methoxybenzo[b]furan-2-carboxylate (50551-57-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 60 ℃; for 12.5h;

Reference yield: 77.0%

2-ethoxycarbonylmethoxy-4-methoxybenzaldehyde (76322-06-0) → ethyl 6-methoxybenzo[b]furan-2-carboxylate (50551-57-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 160 ℃; for 3h;

upstream raw materials:

2-ethoxycarbonylmethoxy-4-methoxybenzaldehyde

2-Hydroxy-4-methoxybenzaldehyde

Diethyl 2-bromomalonate

O-methylresorcine

Downstream raw materials:

6-methoxybenzofuran-2-carboxylic acid

C₁₉H₁₈N₂O₂

(E)-6-(2-(3-oxazolidinyl)ethoxy)-2-(4-dimethylaminostyryl)benzofuran hydrochloride

(E)-4-(2-(6-methoxybenzofuran-2-yl)vinyl)-N-methylaniline

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