2-Iodo-3-Methoxybenzoic acid

Base Information

• Chemical Name: 2-Iodo-3-Methoxybenzoic acid
• CAS No.: 50627-31-1
• Molecular Formula: C8H7IO3
• Molecular Weight: 278.046
• Mol file: 50627-31-1.mol

Synonyms:Benzoic acid,2-iodo-3-methoxy;2-Jod-3-methoxy-benzoesaeure;2-iodo-3-methoxy benzoic acid;

Chemical Property of 2-Iodo-3-Methoxybenzoic acid

Chemical Property:

• PSA: 46.53000
• LogP: 1.99800
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-Iodo-3-methoxybenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Iodo-3-Methoxybenzoic acid

There total 11 articles about 2-Iodo-3-Methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl-2-iodo-3-methoxybenzoate (35387-95-2) → 2-iodo-3-methoxybenzoic acid (50627-31-1)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b01483

Reference yield: 58.0%

3-methoxy-2-pivalamidobenzoic acid (115378-20-6) → 2-iodo-3-methoxybenzoic acid (50627-31-1)

Guidance literature:

With hydrogenchloride; potassium iodide; sodium nitrite; In water;

Reference yield: 53.0%

3-Methoxybenzoic acid (586-38-9) → 2-iodo-3-methoxybenzoic acid (50627-31-1)

Guidance literature:

3-Methoxybenzoic acid; With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at 0 ℃; for 2h;

With iodine; In tetrahydrofuran; at 0 - 65 ℃; for 2.5h;

With hydrogenchloride; at 20 ℃;

DOI:10.1021/ol050761c

upstream raw materials:

3-Methoxybenzoic acid

3-methoxy-2-nitrobenzoic acid

3-methyl-2-nitrophenol

1-methoxy-3-methyl-2-nitro-benzene

Downstream raw materials:

C₈H₆IN₃O₂

methyl-2-iodo-3-methoxybenzoate

3-methoxy-2-(2-methoxyphenylsulfanyl)benzoic acid methyl ester

C₁₅H₁₄N₂O₆

Refernces

• 1、 -. "ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS OR PRECURSORS THEREOF". Sheet 32. . Retrieved 2014/01/17.
• 2、 Pollard, Michael M.,Ter Wiel, Matthijs K. J.,Van Delden, Richard A.,Vicario, Javier,Koumura, Nagatoshi,Van Den Brom, Coenraad R.,Meetsma, Auke,Feringa, Ben L.. "Light-driven rotary molecular motors on gold nanoparticles". supporting information; experimental part. p. 11610 - 11622. Retrieved 2009/12/09.