35387-95-2

Usage

Uses

Used in Organic Synthesis:
Methyl 2-iodo-3-methoxybenzoate is used as a synthetic intermediate for the preparation of various organic compounds. Its reactivity and functional groups allow for a wide range of chemical reactions, making it a versatile building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
Methyl 2-iodo-3-methoxybenzoate is used as a starting material or intermediate in the development of new pharmaceutical agents. Its unique structure can be exploited to design and synthesize novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
Methyl 2-iodo-3-methoxybenzoate is used as a research tool in the study of chemical reactions and mechanisms. Its reactivity and functional groups provide insights into the behavior of similar compounds and contribute to the understanding of organic chemistry.
It is important to handle methyl 2-iodo-3-methoxybenzoate with care, as it may pose health and environmental hazards if not properly managed. Additionally, its potential uses and applications should be carefully considered within the context of safety and regulatory guidelines.

InChI:InChI=1/C9H9IO3/c1-12-7-5-3-4-6(8(7)10)9(11)13-2/h3-5H,1-2H3

Upstream product

• 7664-93-9 sulfuric acid 
• 50627-31-1 2-iodo-3-methoxybenzoic acid 
• 5121-34-6 methyl 2-amino-3-methoxybenzoate 
• 586-38-9 3-Methoxybenzoic acid 
• 1711-05-3 m-anisoyl chloride 
• 420-37-1 trimethoxonium tetrafluoroborate 
• 62924-93-0 N,N-diethyl-3-methoxybenzamide 
• 3177-80-8 2-amino-3-methoxybenzoic acid 
• 74-88-4 methyl iodide 
• 4920-80-3 3-methoxy-2-nitrobenzoic acid 
• 67-56-1 methanol 

Downstream Products

• 2436-96-6 1-nitro-2-(2-nitrophenyl)benzene 
• 855255-32-2 2'-nitro-6-methoxy-biphenyl-carboxylic acid-⁽²⁾ 
• 50627-31-1 2-iodo-3-methoxybenzoic acid 
• 162136-06-3 (2-iodo-3-methoxyphenyl)methanol 
• 101093-92-9 2-Phenoxy-3-methoxy-benzoesaeure-methylester 
• 61260-15-9 dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate 
• 38197-41-0 2,2'-dimethoxycarbonyl-6,6'-dimethoxybiphenyl 

Relevant academic research and scientific papers

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

Monoacylglycerol lipase (MAGL) is the enzyme degrading the endocannabinoid 2-arachidonoylglycerol, and it is involved in several physiological and pathological processes. The therapeutic potential of MAGL is linked to several diseases, including cancer. The development of MAGL inhibitors has been greatly limited by the side effects associated with the prolonged MAGL inactivation. Importantly, it could be preferable to use reversible MAGL inhibitors in vivo, but nowadays only few reversible compounds have been developed. In the present study, structural optimization of a previously developed class of MAGL inhibitors led to the identification of compound 23, which proved to be a very potent reversible MAGL inhibitor (IC50 = 80 nM), selective for MAGL over the other main components of the endocannabinoid system, endowed of a promising antiproliferative activity in a series of cancer cell lines and able to block MAGL both in cell-based as well as in vivo assays.

Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol

In this study we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid, isoochracinic acid, and isoochracinol.

Light-driven rotary molecular motors on gold nanoparticles

We report the synthesis of unidirectional light-driven rotary molecular motors based on chiral overcrowded alkenes and their immobilisation on the surface of gold nanoparticles through two anchors. Using a combination of 1H and 13C N

Phthalazinone derivatives

A method of treatment of a disease of the human or animal body mediated by PARP comprising administering to such a subject a therapeutically effective amount of a compound of formula: or an isomer, salt, solvate, chemically protected form, and prodrug thereof, wherein: A and B together represent an optionally substituted, fused aromatic ring; RC is represented by —L—RL, where L is of formula: —(CH2)n1—Qn2—(CH2)n3— wherein n1, n2 and n3 are each selected from 0, 1, 2 and 3, the sum of n1, n2 and n3 is 1, 2 or 3 and Q is selected from O, S, NH, C(═O) or —CR1R2—, where R1 and R2 are independently selected from hydrogen, halogen or optionally substituted C1-7 alkyl, or may together with the carbon atom to which they are attached form a C3-7 cyclic alkyl group, which may be saturated (a C3-7 cycloalkyl group) or unsaturated (a C3-7 cycloalkenyl group), or one of R1 and R2 may be attached to an atom in RL to form an unsaturated C3-7 cycloalkenyl group which comprises the carbon atoms to which R1 and R2 are attached in Q, —(CH2)n3— (if present) and part of RL; and RL is optionally substituted C5-20 aryl; and RN is selected from hydrogen, optionally substituted C1-7 alkyl, C3-20 heterocyclyl, and C5-20 aryl, hydroxy, ether, nitro, amino, amido, thiol, thioether, sulfoxide and sulfone.