1-Bromo-2,5-bis(methoxymethoxy)-3-methylbenzene

Base Information

• Chemical Name: 1-Bromo-2,5-bis(methoxymethoxy)-3-methylbenzene
• CAS No.: 50848-61-8
• Molecular Formula: C11H15BrO4
• Molecular Weight: 291.142
• DSSTox Substance ID: DTXSID801243807
• Nikkaji Number: J1.421.587E
• Mol file: 50848-61-8.mol

Synonyms:50848-61-8;1-bromo-2,5-bis(methoxymethoxy)-3-methylbenzene;SCHEMBL14514638;DTXSID801243807

Chemical Property of 1-Bromo-2,5-bis(methoxymethoxy)-3-methylbenzene

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 290.01537
• Heavy Atom Count: 16
• Complexity: 191

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1OCOC)Br)OCOC

Technology Process of 1-Bromo-2,5-bis(methoxymethoxy)-3-methylbenzene

There total 5 articles about 1-Bromo-2,5-bis(methoxymethoxy)-3-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1,3-dibromo-2,5-bis(methoxymethoxy)benzene (533884-35-4) + methyl iodide (74-88-4) → 1-bromo-2,5-bis(methoxymethoxy)-3-methylbenzene (50848-61-8)

Guidance literature:

1,3-dibromo-2,5-bis(methoxymethoxy)benzene; With sec.-butyllithium; In tetrahydrofuran;

methyl iodide; In tetrahydrofuran; Further stages.;

DOI:10.1016/j.bmcl.2007.07.009

Reference yield: 57.0%

2-bromo-6-methylbenzene-1,4-diol (50848-60-7) + chloromethyl methyl ether (107-30-2) → 1-bromo-2,5-bis(methoxymethoxy)-3-methylbenzene (50848-61-8)

Guidance literature:

With sodium; In 2-methoxy-ethanol; Ambient temperature;

DOI:10.1016/S0040-4020(01)80058-2

Reference yield:

2-bromo-6-methyl-[1,4]benzoquinone (6293-55-6) → 1-bromo-2,5-bis(methoxymethoxy)-3-methylbenzene (50848-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 38 percent / Na₂S₂O₄ / ethanol; H₂O / 1 h / 60 °C

2: 57 percent / Na / 2-methoxy-ethanol / Ambient temperature

With sodium dithionite; sodium; In ethanol; 2-methoxy-ethanol; water;

DOI:10.1016/S0040-4020(01)80058-2

upstream raw materials:

2-bromo-6-methylbenzene-1,4-diol

chloromethyl methyl ether

1,3-dibromo-2,5-bis(methoxymethoxy)benzene

methyl iodide

Downstream raw materials:

2,5-bis(methoxymethoxy)-1-methyl-3-(2,6,6-trimethylcyclohex-1-enylmethyl)benzene

2,5-bis(methoxymethoxy)-1-methyl-3-<(E,E,E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl>benzene

(+/-)-1-<2,5-bis(methoxymethoxy)-3-methylbenzyl>-3,4,4aα,5,6,7,8,8aα,9,10,10a-dodecahydro-2,4bβ,8,8,10aβ-pentamethylphenanthrene

(4aR,4bS,7S,8aS,10aR)-7-(Benzyloxy)-1-<2,5-bis(methoxymethoxy)-3-methylbenzyl>-3,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-2,4b,8,8,10a-pentamethylphenanthrene