cis-4-(Boc-aMino)cyclohexaneMethylaMine, 97%

Base Information

• Chemical Name: cis-4-(Boc-aMino)cyclohexaneMethylaMine, 97%
• CAS No.: 509143-00-4
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.335
• Mol file: 509143-00-4.mol

Synonyms:cis-(+)-(1S,2R)-5-methoxy-1-methyl-2-(n-dipropylamino)tetralin;cis-(4-aminomethyl-cyclohexyl)-carbamic acid tert-butyl ester;CIS-(+)-5-METHOXY-1-METHYL-2-(DI-N-PROPYLAMINO)TETRALIN MALEATE;cis-(+)-5-methoxy-1-methyl-2-(di-n-propylamino)tetralin;(+)-UH 232 MALEATE;cis-(+)-(1S,2R)-5-methoxy-1-methyl-2-(di-n-propylamino)tetralin;cis-(3,3-dimethoxy-propenyl)-cyclopropane;

Chemical Property of cis-4-(Boc-aMino)cyclohexaneMethylaMine, 97%

Chemical Property:

• Boiling Point: 342.4±11.0 °C(Predicted)
• PKA: 12.52±0.40(Predicted)
• PSA: 64.35000
• Density: 1.01±0.1 g/cm3(Predicted)
• LogP: 3.11980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

cis-4-(Boc-amino)cyclohexylmethylamine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-4-(Boc-aMino)cyclohexaneMethylaMine, 97%

There total 7 articles about cis-4-(Boc-aMino)cyclohexaneMethylaMine, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (1s,4s)-4-(azidomethyl)cyclohexylcarbamate (917022-17-4) → cis-(4-aminomethyl-cyclohexyl)-carbamic acid tert-butyl ester (509143-00-4)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water; at 60 ℃; for 1.5h;

Reference yield:

tert-butyl ((cis)-4-(hydroxymethyl)cyclohexyl)carbamate (223131-01-9) → cis-(4-aminomethyl-cyclohexyl)-carbamic acid tert-butyl ester (509143-00-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 27.5 g / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 60 h / 20 °C

2: hydrazine hydrate / ethanol / 2.25 h / Heating

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; toluene;

DOI:10.1016/j.bmc.2005.12.052

Reference yield:

cis-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid methyl ester (364385-64-8) → cis-(4-aminomethyl-cyclohexyl)-carbamic acid tert-butyl ester (509143-00-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 301 g / lithium aluminum hydride / diethyl ether / 2 h / 20 °C

2: 27.5 g / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 60 h / 20 °C

3: hydrazine hydrate / ethanol / 2.25 h / Heating

With lithium aluminium tetrahydride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; toluene;

DOI:10.1016/j.bmc.2005.12.052

upstream raw materials:

cis-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid methyl ester

cis-4-aminocyclohexane-1-carboxylic acid

methyl (1s,4s)-4-aminocyclohexane-1-carboxylate

tert-butyl ((cis)-4-(hydroxymethyl)cyclohexyl)carbamate

Downstream raw materials:

{cis-4-[(3,4-difluoro-benzoylamino)-methyl]-cyclohexyl}-carbamic acid tert-butyl ester

cis-(4-amino-cyclohexylmethyl)-carbamic acid benzyl ester