Methyl cis-4-(Boc-aMino)cyclohexanecarboxylate

Base Information

• Chemical Name: Methyl cis-4-(Boc-aMino)cyclohexanecarboxylate
• CAS No.: 364385-64-8
• Molecular Formula: C13H23NO4
• Molecular Weight: 257.33
• Hs Code.: 2920907090
• Mol file: 364385-64-8.mol

Synonyms:Methyl cis-4-(Boc-aMino)cyclohexanecarboxylate;cis-Methyl 4-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate

Chemical Property of Methyl cis-4-(Boc-aMino)cyclohexanecarboxylate

Chemical Property:

• PSA: 64.63000
• LogP: 2.63380

Purity/Quality:

97% ^*data from raw suppliers

Methylcis-4-(Boc-amino)cyclohexanecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl cis-4-(Boc-aMino)cyclohexanecarboxylate

There total 7 articles about Methyl cis-4-(Boc-aMino)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl acetate n-hexane + cis-4-tert-butoxycarbonylaminocyclohexane-1-ylcarboxylic acid (53292-90-3) + diazomethyl-trimethyl-silane (18107-18-1) → cis-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid methyl ester (364385-64-8)

Guidance literature:

In methanol-benzene; hexane;

Reference yield: 51.0%

di-tert-butyl dicarbonate (24424-99-5) + cis-4-aminocyclohexanecarboxylic acid methyl ester hydrochloride (61367-16-6) → cis-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid methyl ester (364385-64-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 16h; Inert atmosphere;

Reference yield:

methanol (67-56-1) + carbon monoxide (201230-82-2) + N-Boc-4-iodoaminocyclohexane → methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate (146307-51-9) + cis-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid methyl ester (364385-64-8)

Guidance literature:

With indium; copper(I) triflate; magnesium carbonate; In 1,4-dioxane; at 25 ℃; for 24h; under 760.051 Torr; Overall yield = 70 %; Overall yield = 54.0 mg; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01573

upstream raw materials:

di-tert-butyl dicarbonate

cis-4-aminocyclohexanecarboxylic acid methyl ester hydrochloride

methyl (1s,4s)-4-aminocyclohexane-1-carboxylate

cis-4-aminocyclohexane-1-carboxylic acid

Downstream raw materials:

cis-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexanamine

tert-butyl (cis-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)carbamate

tert-butyl ((1s,4s)-4-(2-oxoethyl)cyclohexyl)carbamate

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