3-Pyridinamine, 2-chloro-N-(4-methylphenyl)-

Base Information

Chemical Name:3-Pyridinamine, 2-chloro-N-(4-methylphenyl)-
CAS No.:509953-51-9
Molecular Formula:C12H11ClN2
Molecular Weight:218.68200
Hs Code.:
DSSTox Substance ID:DTXSID30458737
Nikkaji Number:J2.091.036D
Wikidata:Q82282236
Mol file:509953-51-9.mol

Synonyms:509953-51-9;3-Pyridinamine, 2-chloro-N-(4-methylphenyl)-;DTXSID30458737;2-Chloro-N-(4-methylphenyl)pyridine-3-amine

Suppliers and Price of 3-Pyridinamine, 2-chloro-N-(4-methylphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Pyridinamine, 2-chloro-N-(4-methylphenyl)-

Chemical Property:

PSA：24.92000
LogP:3.86000
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:218.0610761
Heavy Atom Count:15
Complexity:190

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)NC2=C(N=CC=C2)Cl

Technology Process of 3-Pyridinamine, 2-chloro-N-(4-methylphenyl)-

There total 4 articles about 3-Pyridinamine, 2-chloro-N-(4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 78607-36-0
2-chloro-3-iodopyridine

: 106-49-0,12221-03-3
p-toluidine

: 509953-51-9
2-chloro-N-(4-methylphenyl)pyridin-3-ylamine

Guidance literature:: With caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,4-dioxane; for 17h; Heating;
DOI:10.1055/s-2002-35579

Reference yield: 82.0%

: 106-49-0,12221-03-3
p-toluidine

: 830324-68-0
3-(2-chloro-3-pyridyl)-3,4-dihydro-4-oxo-2-quinazolinecarboxylic acid ethyl ester

: 509953-51-9
2-chloro-N-(4-methylphenyl)pyridin-3-ylamine

Guidance literature:: With sodium methylate; In tetrahydrofuran; at 20 ℃;
DOI:10.1055/s-2004-834805 DOI:10.1016/j.tet.2005.02.038

Reference yield:

: 956-30-9
2-amino-N-(2-chloropyridin-3-yl)benzamide

: 509953-51-9
2-chloro-N-(4-methylphenyl)pyridin-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / pyridine / tetrahydrofuran / 0.25 h / 0 °C

2: 100 percent / Et₃N; trimethylsilyl chloride / 1,2-dichloro-ethane / 1.5 h / 80 °C

3: 82 percent / NaOMe / tetrahydrofuran / 20 °C

With pyridine; chloro-trimethyl-silane; sodium methylate; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2005.02.038