(3,5-Dibromo-4-methoxyphenyl)(2-ethyl-3-benzofuranyl)-methanone

Base Information

• Chemical Name: (3,5-Dibromo-4-methoxyphenyl)(2-ethyl-3-benzofuranyl)-methanone
• CAS No.: 51073-13-3
• Molecular Formula: C18H14Br2O3
• Molecular Weight: 438.115
• Mol file: 51073-13-3.mol

Synonyms:benzbromarone methyl ether;

Chemical Property of (3,5-Dibromo-4-methoxyphenyl)(2-ethyl-3-benzofuranyl)-methanone

Chemical Property:

• Vapor Pressure: 1.5E-11mmHg at 25°C
• Boiling Point: 535.7oC at 760 mmHg
• Flash Point: 277.8oC
• PSA: 39.44000
• Density: 1.601g/cm3
• LogP: 5.75980

Purity/Quality:

98%min ^*data from raw suppliers

(3,5-Dibromo-4-methoxyphenyl)-(2-ethylbenzofuran-3-yl)methanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3,5-Dibromo-4-methoxyphenyl)(2-ethyl-3-benzofuranyl)-methanone

There total 8 articles about (3,5-Dibromo-4-methoxyphenyl)(2-ethyl-3-benzofuranyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzbromarone (3562-84-3) + methyl iodide (74-88-4) → benzbromarone methyl ether (51073-13-3)

Guidance literature:

With potassium carbonate; In acetone; for 16h; Heating / reflux;

Reference yield: 86.0%

benzbromarone (3562-84-3) + diazomethyl-trimethyl-silane (18107-18-1) → benzbromarone methyl ether (51073-13-3)

Guidance literature:

benzbromarone; With N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; for 0.166667h;

diazomethyl-trimethyl-silane; In methanol; hexane; acetonitrile; at 20 ℃;

DOI:10.1021/acs.orglett.1c04038

Reference yield:

2-ethylbenzofuran (3131-63-3) → benzbromarone methyl ether (51073-13-3)

Guidance literature:

Multi-step reaction with 4 steps

1: tin (IV)-chloride; carbon disulfide

2: pyridine hydrochloride

3: aqueous acetic acid; bromine

4: ethanolic KOH-solution

With carbon disulfide; potassium hydroxide; bromine; pyridine hydrochloride; tin(IV) chloride; acetic acid;

upstream raw materials:

benzbromarone

methyl iodide

2-ethylbenzofuran

benzarone

Refernces

• 1、 -. "DEVELOPING POTENT URATE TRANSPORTER INHIBITORS: COMPOUNDS DESIGNED FOR THEIR URICOSURIC ACTION". Page/Page column 42. . Retrieved 2012/04/23.