5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene

Base Information

• Chemical Name: 5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene
• CAS No.: 511540-64-0
• Molecular Formula: C13H4BrF7O
• Molecular Weight: 389.067
• Mol file: 511540-64-0.mol

Synonyms:5-Bromo-2-[difluoro(3,4,5-trifluorophenoxy)methyl]-1,3-difluorobenzene;

Chemical Property of 5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene

Chemical Property:

• Vapor Pressure: 0.000246mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 334.579 °C at 760 mmHg
• Flash Point: 189.99 °C
• PSA: 9.23000
• Density: 1.744 g/cm³
• LogP: 5.27290

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene

There total 11 articles about 5-((4-BroMo-2,6-difluorophenyl)difluoroMethoxy)-1,2,3-trifluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-bromo-2,6-difluorothionobenzoic acid 3,4,5-trifluorophenyl ester → 4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-1-bromo-3,5-difluorobenzene (511540-64-0)

Guidance literature:

With hydrogen fluoride; bromine; In tetrahydrofuran; 1,2-dichloro-ethane; at 60 ℃; for 4h; Inert atmosphere;

Reference yield: 88.0%

C7H2BrF5O + 5-bromo-1,3-difluoro-2-iodo-benzene (160976-02-3) → 4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-1-bromo-3,5-difluorobenzene (511540-64-0)

Guidance literature:

With copper; In dimethyl sulfoxide; at 80 ℃; for 24h; Reagent/catalyst; Solvent; Temperature;

Reference yield: 36.0%

4-bromo-2,6-difluoro-(bromodifluoromethyl)benzene + 3,4,5-trifluorophenol (99627-05-1) → 4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-1-bromo-3,5-difluorobenzene (511540-64-0)

Guidance literature:

3,4,5-trifluorophenol; With tetrabutylammomium bromide; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

4-bromo-2,6-difluoro-(bromodifluoromethyl)benzene; In N,N-dimethyl-formamide; at 110 ℃; for 1h;

upstream raw materials:

5-bromo-1,3-difluoro-2-iodo-benzene

3,4,5-trifluorophenol

ethyl 2,2-difluoro-2-(3,4,5-trifluorophenoxy)acetate

2,2-difluoro-2-(3,4,5-trifluorophenoxy)acetic acid

Downstream raw materials:

SUQU-2-F

4-[difluoro-(3,4,5-trifluorophenoxy)methyl]-3,5-difluoro-4'-propylbiphenyl

{4-[difluoro(3,4,5-trifluorophenoxy)methyl]-3,5-difluorophenyl}boronic acid