Glycine, N-[[(4-methoxyphenyl)methoxy]carbonyl]-, 4-nitrophenyl ester

Base Information

• Chemical Name: Glycine, N-[[(4-methoxyphenyl)methoxy]carbonyl]-, 4-nitrophenyl ester
• CAS No.: 51165-13-0
• Molecular Formula: C17H16N2O7
• Molecular Weight: 360.31800
• Mol file: 51165-13-0.mol

Synonyms:(4-Methoxy-benzyloxycarbonylamino)-acetic acid 4-nitro-phenyl ester;Z(OMe)-Gly-ONp;

Chemical Property of Glycine, N-[[(4-methoxyphenyl)methoxy]carbonyl]-, 4-nitrophenyl ester

Chemical Property:

• Boiling Point: 572.2±50.0 °C(Predicted)
• PSA: 119.68000
• Density: 1.339±0.06 g/cm3(Predicted)
• LogP: 3.34930

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[[(4-methoxyphenyl)methoxy]carbonyl]-, 4-nitrophenyl ester

There total 1 articles about Glycine, N-[[(4-methoxyphenyl)methoxy]carbonyl]-, 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + N-(4-methoxy-benzyloxycarbonyl)-glycine (4596-54-7) → Z-(OMe)-Gly-ONp (51165-13-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1248/cpb.43.2133

Reference yield: 90.0%

H-Leu-Val-NH2 (65756-33-4) + Z-(OMe)-Gly-ONp (51165-13-0) → Z(OMe)-Gly-Leu-Val-NH2 (101301-21-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.3205

Reference yield: 87.0%

Z-(OMe)-Gly-ONp (51165-13-0) + L-Phe-L-MetNH2 (64563-22-0) → Z(OMe)-Gly-Phe-Met-NH2 (76939-29-2)

Guidance literature:

With benzotriazol-1-ol; triethylamine; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1248/cpb.28.2580

upstream raw materials:

4-nitro-phenol

N-(4-methoxy-benzyloxycarbonyl)-glycine

Downstream raw materials:

Z(OMe)-Gly-Leu-Val-NH₂

Z(OMe)-Gly-Leu-Leu-OMe

Z(OMe)-Gly-Asp(OBzl)-OH

Z(OMe)-Gly-Phe-Met-NH₂

Refernces