2-[(Difluoromethyl)sulfonyl]aniline

Base Information

Chemical Name:2-[(Difluoromethyl)sulfonyl]aniline
CAS No.:24906-75-0
Molecular Formula:C₇H₇F₂NO₂S
Molecular Weight:207.201
Hs Code.:2921420090
European Community (EC) Number:863-855-6
ChEMBL ID:CHEMBL1706459
Mol file:24906-75-0.mol

Synonyms:2-[(difluoromethyl)sulfonyl]aniline;24906-75-0;2-(difluoromethylsulfonyl)aniline;2-((difluoromethyl)sulfonyl)aniline;2-difluoromethanesulfonylaniline;MLS000767378;SCHEMBL1000354;CHEMBL1706459;HMS2790N06;MFCD00521859;STK530345;AKOS000122892;AT38853;2-(Difluoro-methanesulfonyl)-phenylamine;SMR000429709;Benzenamine, 2-[(difluoromethyl)sulfonyl]-;EN300-31819;Z56827431

Suppliers and Price of 2-[(Difluoromethyl)sulfonyl]aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Difluoromethanesulfonylaniline
5mg
$ 175.00

Crysdot
2-((Difluoromethyl)sulfonyl)anilinehydrochloride 97%
1g
$ 564.00

American Custom Chemicals Corporation
2-[(DIFLUOROMETHYL)SULFONYL]ANILINE HYDROCHLORIDE 95.00%
5G
$ 1928.08

American Custom Chemicals Corporation
2-[(DIFLUOROMETHYL)SULFONYL]ANILINE HYDROCHLORIDE 95.00%
2.5G
$ 1473.14

American Custom Chemicals Corporation
2-[(DIFLUOROMETHYL)SULFONYL]ANILINE HYDROCHLORIDE 95.00%
1G
$ 983.52

Total 8 raw suppliers

Chemical Property of 2-[(Difluoromethyl)sulfonyl]aniline

Chemical Property:

Vapor Pressure:2.06E-05mmHg at 25°C
Melting Point:65-66 °C
Refractive Index:1.52
Boiling Point:361.5 °C at 760 mmHg
PKA:-1.90±0.10(Predicted)
Flash Point:172.5 °C
PSA：68.54000
Density:1.431 g/cm³
LogP:3.72910
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:207.01655596
Heavy Atom Count:13
Complexity:260

Purity/Quality:

99% ^*data from raw suppliers

2-Difluoromethanesulfonylaniline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)N)S(=O)(=O)C(F)F
Uses 2-Difluoromethanesulfonylaniline can be used as protein kinase inhibitors for treating proliferative disorders, immune disorders, and infections.

Technology Process of 2-[(Difluoromethyl)sulfonyl]aniline

There total 2 articles about 2-[(Difluoromethyl)sulfonyl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1155-00-6
bis(2-nitrophenyl)disulfide

: 24906-75-0
<2-Amino-phenyl>-difluormethyl-sulfon

Guidance literature:: Multi-step reaction with 3 steps

1: (i) aq. NaOH, H₂S, (ii) /BRN= 1731036/

2: CrO₃ / acetic acid

3: aq. HCl, SnCl₂

With chromium(VI) oxide; hydrogenchloride; tin(ll) chloride; In acetic acid;

Reference yield:

: 24933-38-8
(difluoromethyl)(2-nitrophenyl)sulfane

: 24906-75-0
<2-Amino-phenyl>-difluormethyl-sulfon

Guidance literature:: Multi-step reaction with 2 steps

1: CrO₃ / acetic acid

2: aq. HCl, SnCl₂

With chromium(VI) oxide; hydrogenchloride; tin(ll) chloride; In acetic acid;

Reference yield:

: 24906-75-0
<2-Amino-phenyl>-difluormethyl-sulfon

: 63647-61-0
o-Difluormethylsulfonyltrifluormethylthiophenol

Guidance literature:: Multi-step reaction with 2 steps

1: (i) aq. HCl, NaNO₂, (ii) SO₂, CuCl₂, (iii) I₂, phosphorus

2: liquid ammonia / Irradiation

In ammonia;