2-BroMo-3-Methylbutenoic Acid Methyl Ester

Base Information

• Chemical Name: 2-BroMo-3-Methylbutenoic Acid Methyl Ester
• CAS No.: 51263-40-2
• Molecular Formula: C6H9BrO2
• Molecular Weight: 193.03800
• Hs Code.: 2916190090
• Mol file: 51263-40-2.mol

Synonyms:2-bromo-3-methyl-crotonic acid methyl ester;2-butenoic acid,2-bromo-3-methyl-,methyl ester;methyl 2-bromo-2-methylbut-2-enoate;methyl 2-bromo-senecioate;methyl-2-bromo-3-methyl-2-butenoate;2-Bromo-3-methylbutenoic acid methyl ester;2-Brom-3-methyl-crotonsaeure-methylester;

Chemical Property of 2-BroMo-3-Methylbutenoic Acid Methyl Ester

Chemical Property:

• Vapor Pressure: 0.549mmHg at 25°C
• Boiling Point: 190.2oC at 760 mmHg
• Flash Point: 68.8oC
• PSA: 26.30000
• Density: 1.404g/cm3
• LogP: 1.84820
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

2-Bromo-3-methylbutenoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-3-Methylbutenoic Acid Methyl Ester

There total 7 articles about 2-BroMo-3-Methylbutenoic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,3-dibromo-3-metyl-butenoate (63881-44-7) → methyl 2-bromo-3-methylbut-2-enoate (51263-40-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at -78 ℃; for 1.5h;

DOI:10.1021/jo980955o

Reference yield: 77.0%

Methyl 3,3-dimethylacrylate (924-50-5) → methyl 2-bromo-3-methylbut-2-enoate (51263-40-2)

Guidance literature:

Methyl 3,3-dimethylacrylate; With bromine; In tetrachloromethane; at 25 ℃; for 1h;

With triethylamine; In dichloromethane; at 0 - 25 ℃;

DOI:10.1016/S0040-4020(00)00258-1

Reference yield:

trimethyl phosphonoacetate (5927-18-4) → methyl 2-bromo-3-methylbut-2-enoate (51263-40-2)

Guidance literature:

With bromine; In tetrahydrofuran; water; acetone;

upstream raw materials:

diazomethane

2-bromo-3-methyl-crotonic acid

2,3-dibromo-3-metyl-butenoate

2-bromo-3-chloro-3-methyl-butenoate

Downstream raw materials:

methyl 2-methoxy-3-methyl-2-butenoate

3,3-Dimethyl-2-(4-tolyloxy)-acrylsaeuremethylester

3-Methyl-2-<2,6-dimethyl-phenoxy>-buten-(3)-saeuremethylester

3,3-Dimethyl-2-phenoxy-acrylsaeure-methylester

Refernces

• 1、 Mori, Hajime,Ikoma, Keiichi,Katsumura, Shigeo. "Further demonstration of the higher reactivity of the vinyl hydrogen rather than the allyl hydrogen towards singlet oxygen". . p. 2243 - 2244. Retrieved 1997.
• 2、 Lloveras, Maia,Ramos, Isabel,Molins, Elies,Messeguer, Angel. "Improved synthesis of three brominated analogues of the potent environmental mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)". . p. 3391 - 3397. Retrieved 2007/10/03.