N-tert-Butyl-N-hydroxyacetamide

Base Information

• Chemical Name: N-tert-Butyl-N-hydroxyacetamide
• CAS No.: 51338-95-5
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• DSSTox Substance ID: DTXSID00515624
• Nikkaji Number: J3.655.038D
• Wikidata: Q82376585
• Mol file: 51338-95-5.mol

Synonyms:N-tert-Butyl-N-hydroxyacetamide;51338-95-5;SCHEMBL3280228;DTXSID00515624

Chemical Property of N-tert-Butyl-N-hydroxyacetamide

Chemical Property:

• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 115

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C(C)(C)C)O

Technology Process of N-tert-Butyl-N-hydroxyacetamide

There total 1 articles about N-tert-Butyl-N-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butylacetamide (762-84-5) → N-hydroxy-N-(1,1-dimethylethyl)ethanamide (51338-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N

2: (i) MoO₅*2DMF, (ii) Na₂H₂edta

With triethylamine;

Reference yield:

Lawessons reagent (19172-47-5,94367-93-8) + N-hydroxy-N-(1,1-dimethylethyl)ethanamide (51338-95-5) → N-tert-butyl-N-hydroxy-thioacetamide + C13H20NO4PS + N-tert-butylacetamide (762-84-5) + N-tert-butylethanethioamide (21351-31-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h; Further byproducts given. Title compound not separated from byproducts;

DOI:10.1002/hc.20259

upstream raw materials:

N-tert-butylacetamide

Downstream raw materials:

N-tert-butylacetamide

N-tert-butylethanethioamide