Phe-Thr

Base Information

• Chemical Name: Phe-Thr
• CAS No.: 51352-44-4
• Molecular Formula: C13H18N2O4
• Molecular Weight: 266.297
• Wikidata: Q27142890
• Mol file: 51352-44-4.mol

Synonyms:Phe-Thr;L-phenylalanyl-L-threonine;Phenylalanyl-Threonine;phenylalanylthreonine;FT dipeptide;F-T Dipeptide;L-Phe-L-Thr;SCHEMBL8525812;Phenylalanine Threonine dipeptide;Phenylalanine-Threonine dipeptide;CHEBI:73636;Q27142890;F-T

Chemical Property of Phe-Thr

Chemical Property:

• XLogP3: -3
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 266.12665706
• Heavy Atom Count: 19
• Complexity: 316

Purity/Quality:

≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C(C(=O)O)NC(=O)C(CC1=CC=CC=C1)N)O
• Isomeric SMILES: C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)N)O

Technology Process of Phe-Thr

There total 7 articles about Phe-Thr which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

Z-Phe-Thr-OH*DCHA (109481-35-8) → H-Phe-Thr-OH (51352-44-4)

Guidance literature:

With hydrogen; palladium; In methanol;

Reference yield:

N-Fmoc L-Phe (35661-40-6) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) → H-Phe-Thr-OH (51352-44-4)

Guidance literature:

Fmoc-Thr(tBu)-OH; With 1-methyl-1H-imidazole; diisopropyl-carbodiimide; at 20 ℃; for 2h; Green chemistry;

With piperidine; In N,N-dimethyl-formamide; for 0.133333h; Green chemistry;

N-Fmoc L-Phe; Further stages; Green chemistry;

DOI:10.1016/j.tetlet.2019.151058

Reference yield:

(S)-benzyl 1-azido-1-oxo-3-phenylpropan-2-ylcarbamate (62067-14-5) → H-Phe-Thr-OH (51352-44-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / dimethylformamide

2: 67 percent / NaOH / dioxane; H₂O

3: 82 percent / H₂ / Pd / methanol

With sodium hydroxide; hydrogen; palladium; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

N-(N-benzyloxycarbonyl-phenylalanyl)-allothreonine

Z-DL-Phe-OH

Z-Phe-Thr-OH*DCHA

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

Z-Lys(Boc)-Thr-Phe-Thr-OH

H-Lys-Thr-Phe-Thr-OH