2-Ethoxypyridin-3-amine

Base Information

• Chemical Name: 2-Ethoxypyridin-3-amine
• CAS No.: 51468-01-0
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.169
• Hs Code.: 2933399090
• European Community (EC) Number: 872-213-4
• ChEMBL ID: CHEMBL3277158
• DSSTox Substance ID: DTXSID50588565
• Wikidata: Q82481311
• Mol file: 51468-01-0.mol

Synonyms:2-ethoxypyridin-3-amine;51468-01-0;3-Pyridinamine, 2-ethoxy-;2-Ethoxy-3-pyridinamine;3-pyridinamine,2-ethoxy-;3-amino-2-ethoxypyridine;SCHEMBL1647418;CHEMBL3277158;DTXSID50588565;OKSTUZYCGUDGOA-UHFFFAOYSA-N;BCA46801;MFCD09738392;STL253606;ZB1050;AKOS000145411;MCULE-1259942697;SB52708;BS-13216;DB-093769;CS-0119946;EN300-37457;F20019;Z240084312

Chemical Property of 2-Ethoxypyridin-3-amine

Chemical Property:

• Melting Point: 31-32 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 105-106 °C(Press: 10 Torr)
• PKA: 4.97±0.22(Predicted)
• PSA: 48.14000
• Density: 1.101±0.06 g/cm3(Predicted)
• LogP: 1.64370
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-ethoxypyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=C(C=CC=N1)N

Technology Process of 2-Ethoxypyridin-3-amine

There total 3 articles about 2-Ethoxypyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-ethoxy-3-nitro-pyridine (31594-44-2) → 3-amino-2-ethoxypyridine (51468-01-0)

Guidance literature:

With hydrogen; 10% palladium on activated carbon; In ethanol; ethyl acetate; for 0.5h; under 568.878 - 2068.65 Torr;

Reference yield:

2-chloro-3-aminopyridine (6298-19-7) → 3-amino-2-ethoxypyridine (51468-01-0)

Guidance literature:

With sodium ethanolate; at 150 ℃;

Reference yield:

→ 3-amino-2-ethoxypyridine (51468-01-0)

Guidance literature:

2-Chlor-3-amino-pyridin, Na-Ethylat (10 h, 150grad, im Autokl.);

upstream raw materials:

2-chloro-3-aminopyridine

2-ethoxy-3-nitro-pyridine

Downstream raw materials:

N-(2-ethoxy-[3]pyridyl)-acetamide

2-chloro-3-aminopyridine