3-Nitro-2-(1-pyrrolidinyl)pyridine

Base Information

• Chemical Name: 3-Nitro-2-(1-pyrrolidinyl)pyridine
• CAS No.: 26820-73-5
• Molecular Formula: C9H11 N3 O2
• Molecular Weight: 193.2
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30377479
• Wikidata: Q82166711
• Mol file: 26820-73-5.mol

Synonyms:3-nitro-2-(pyrrolidin-1-yl)pyridine;26820-73-5;3-nitro-2-(1-pyrrolidinyl)pyridine;3-nitro-2-pyrrolidin-1-ylpyridine;SCHEMBL6708175;DTXSID30377479;BBA82073;MFCD03001300;AKOS000264994;SB53488;3-nitro-2-(pyrrolidine-1-yl) pyridine;CS-0450357;FT-0680738;EN300-714117;9R-0201;J-512960

Chemical Property of 3-Nitro-2-(1-pyrrolidinyl)pyridine

Chemical Property:

• Vapor Pressure: 9.44E-05mmHg at 25°C
• Melting Point: 42 °C
• Boiling Point: 339°Cat760mmHg
• PKA: 3.02±0.29(Predicted)
• Flash Point: 158.8°C
• PSA: 61.95000
• Density: 1.296g/cm³
• LogP: 2.17820
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 193.085126602
• Heavy Atom Count: 14
• Complexity: 211

Purity/Quality:

97% ^*data from raw suppliers

3-Nitro-2-(1-pyrrolidinyl)pyridine >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)C2=C(C=CC=N2)[N+](=O)[O-]

Technology Process of 3-Nitro-2-(1-pyrrolidinyl)pyridine

There total 6 articles about 3-Nitro-2-(1-pyrrolidinyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrrolidine (123-75-1) + 2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 3-nitro-2-(pyrrolidin-1-yl)pyridine (26820-73-5)

Guidance literature:

In dimethyl sulfoxide; at 25 ℃;

DOI:10.1002/kin.20297

Reference yield: 92.0%

pyrrolidine (123-75-1) + 3-nitro-2-(2,2,2-trifluoroethoxy)pyridine → 3-nitro-2-(pyrrolidin-1-yl)pyridine (26820-73-5)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 80 ℃; for 20h;

DOI:10.1021/acs.joc.8b02453

Reference yield: 88.2%

pyrrolidine (123-75-1) + 2-fluoro-3-nitropyridine (1480-87-1) → 3-nitro-2-(pyrrolidin-1-yl)pyridine (26820-73-5)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 100 ℃; for 16h; Sealed tube;

upstream raw materials:

pyrrolidine

2-Chloro-3-nitropyridine

3-nitropyridine-2-phenyl ether

2-fluoro-3-nitropyridine

Downstream raw materials:

2-(pyrrolidin-1-yl)pyridin-3-amine