3-Azidophenol

Base Information

• Chemical Name: 3-Azidophenol
• CAS No.: 51642-25-2
• Molecular Formula: C6H5N3O
• Molecular Weight: 135.125
• European Community (EC) Number: 851-856-4
• Nikkaji Number: J1.112.691J
• Mol file: 51642-25-2.mol

Synonyms:3-azidophenol;m-azidophenol;51642-25-2;OMXOPNUFEVXGPU-UHFFFAOYSA-N;EN300-734428

Chemical Property of 3-Azidophenol

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 135.043261791
• Heavy Atom Count: 10
• Complexity: 153

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)O)N=[N+]=[N-]

Technology Process of 3-Azidophenol

There total 4 articles about 3-Azidophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

m-Hydroxyaniline (591-27-5) → 3-azidophenol (51642-25-2)

Guidance literature:

m-Hydroxyaniline; With hydrogenchloride; sodium nitrite; In water; for 0.5h;

With sodium azide; In water; at 20 ℃; for 3h;

DOI:10.1021/acs.joc.9b01133

Reference yield: 65.0%

3-hydroxyphenylboronic acid (87199-18-6) → 3-azidophenol (51642-25-2)

Guidance literature:

With sodium azide; In methanol; at 20 ℃; for 20h; Green chemistry;

DOI:10.1002/cctc.201902058

Reference yield:

1-<(tert-butyldimethylsilyl)oxy>-3-(tritylamino)benzene → 3-azidophenol (51642-25-2)

Guidance literature:

With sodium azide; water; acetic acid; sodium nitrite; Yield given. Multistep reaction; 1) 25 deg C, 2) H₂O, 0 deg C;

DOI:10.1021/jm00121a046

upstream raw materials:

m-Hydroxyaniline

3-hydroxyphenylboronic acid

Downstream raw materials:

C₂₄H₂₀NOP

dimethyl 1-(3-hydroxyphenyl)-1H-1,2,3-triazole-4,5-dicarboxylate

3-hydroxyformanilide

tert-butyl 3-hydroxyphenylcarbamate