N-BOC-3-AMINOPHENOL

Base Information

• Chemical Name: N-BOC-3-AMINOPHENOL
• CAS No.: 19962-06-2
• Molecular Formula: C11H15 N O3
• Molecular Weight: 209.245
• Hs Code.: 2924299090
• Mol file: 19962-06-2.mol

Synonyms:Carbamicacid, (3-hydroxyphenyl)-, 1,1-dimethylethyl ester (9CI); Carbanilic acid,m-hydroxy-, tert-butyl ester (8CI); 1,1-Dimethylethyl(3-hydroxyphenyl)carbamate; 3-(tert-Butoxycarbonylamino)phenol; NSC 222586;tert-Butyl 3-hydroxyphenylcarbamate

Chemical Property of N-BOC-3-AMINOPHENOL

Chemical Property:

• Vapor Pressure: 0.00149mmHg at 25°C
• Melting Point: 134-138 °C(lit.)
• Boiling Point: 286.8°Cat760mmHg
• PKA: 9.69±0.10(Predicted)
• Flash Point: 127.3°C
• PSA: 58.56000
• Density: 1.182g/cm³
• LogP: 2.81220
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl3-Hydroxyphenylcarbamate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N-BOC-3-AMINOPHENOL

There total 4 articles about N-BOC-3-AMINOPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + m-Hydroxyaniline (591-27-5) → tert-butyl 3-hydroxyphenylcarbamate (19962-06-2)

Guidance literature:

In tetrahydrofuran; Reflux;

DOI:10.1016/j.bmc.2013.09.010

Reference yield: 94.0%

tert-butyl (3-cyano-4,6-dimethylpyridin-2-yl) carbonate + m-Hydroxyaniline (591-27-5) → tert-butyl 3-hydroxyphenylcarbamate (19962-06-2)

Guidance literature:

In ethanol; for 1h; Reflux;

DOI:10.1039/c9nj00885c

Reference yield: 89.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-azidophenol (51642-25-2) → tert-butyl 3-hydroxyphenylcarbamate (19962-06-2)

Guidance literature:

With hydrogen; Lindlar's catalyst; In methanol; at 20 ℃; for 6h; under 760 Torr;

upstream raw materials:

di-tert-butyl dicarbonate

m-Hydroxyaniline

3-azidophenol

tert-butyl 3-hydroxyphenyl(3-perfluorooctylpropoxy)carbamate

Downstream raw materials:

methyl 4-{3-[(tert-butoxycarbonyl)amino]phenoxy}-2-nitro-4-phenylbutanoate

1,1-dimethylethyl (3-{[4-(ethylamino)-5-nitro-2-pyridinyl]oxy}phenyl)carbamate

1,1-dimethylethyl (3-{[5-nitro-4-({4-[(phenylmethyl)oxy]phenyl}amino)-2-pyridinyl]oxy}phenyl)carbamate

5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester

Refernces

• 1、 Yaqoob, Sana,Nasim, Nourina,Khanam, Rahila,Wang, Yan,Jabeen, Almas,Qureshi, Urooj,Ul-Haq, Zaheer,El-Seedi, Hesham R.,Jiang, Zi-Hua,Khan, Farooq-Ahmad. "Synthesis of highly potent anti-inflammatory compounds (ROS inhibitors) from isonicotinic acid". . . Retrieved 2021/05/31.
• 2、 Garad, Dnyaneshwar N.,Ingale, Ajit P.,Shinde, Sandeep V.,Ukale, Dattatraya. "Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions". supporting information. p. 1656 - 1668. Retrieved 2021/04/05.