2-Propenoic acid, 3-(4-cyanophenyl)-, 1,1-dimethylethyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(4-cyanophenyl)-, 1,1-dimethylethyl ester, (2E)-
• CAS No.: 516520-65-3
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.279
• Mol file: 516520-65-3.mol

Synonyms:2-Propenoic acid,3-(4-cyanophenyl)-,1,1-dimethylethyl ester;2-Propenoic acid,3-(4-cyanophenyl)-,1,1-dimethylethyl ester,(2E);

Chemical Property of 2-Propenoic acid, 3-(4-cyanophenyl)-, 1,1-dimethylethyl ester, (2E)-

Chemical Property:

• PSA: 50.09000
• LogP: 2.91318

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Cyano-phenyl)-acrylicacidtert-butylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-(4-cyanophenyl)-, 1,1-dimethylethyl ester, (2E)-

There total 5 articles about 2-Propenoic acid, 3-(4-cyanophenyl)-, 1,1-dimethylethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl diethylphosphonoacetate (27784-76-5) + 4-cyanobenzaldehyde (105-07-7) → (E)‐tert‐butyl 3‐(4‐cyanophenyl)acrylate (516520-65-3)

Guidance literature:

tert-butyl diethylphosphonoacetate; With sodium hydride; In tetrahydrofuran; at 20 - 35 ℃; for 1h;

4-cyanobenzaldehyde; In tetrahydrofuran; at 20 - 35 ℃; for 1.5h;

Reference yield: 100.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 4-iodobenzonitrile (3058-39-7) → (E)‐tert‐butyl 3‐(4‐cyanophenyl)acrylate (516520-65-3)

Guidance literature:

With C₃₆H₃₆Cl₂N₆Pd; triethylamine; In methanol; at 70 ℃; for 24h;

DOI:10.1016/j.jorganchem.2013.08.016

Reference yield: 94.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 4-bromobenzenecarbonitrile (623-00-7) → (E)‐tert‐butyl 3‐(4‐cyanophenyl)acrylate (516520-65-3)

Guidance literature:

With palladium on silica; triethylamine; In N,N-dimethyl-formamide; for 0.2h; Microwave irradiation; Green chemistry;

DOI:10.1039/c4ra01813c

upstream raw materials:

tert-Butyl acrylate

4-bromobenzenecarbonitrile

4-cyanophenylboronic acid

4-iodobenzonitrile

Downstream raw materials:

4-{(1S, 2S)-2-[((R)-4-cyclobutyl-2-methylpiperazin-1-yl)carbonyl]-cyclopropyl}-benzamide

4-((trans)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzamide

4-((trans)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzamide

(R)-tert-butyl 4-(trans-2-(4-carbamoylphenyl)cyclopropanecarbonyl)-3-methylpiperazine-1-carboxylate

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