Benzenepropanoic acid, 3-bromo-b-hydroxy-, ethyl ester

Base Information

• Chemical Name: Benzenepropanoic acid, 3-bromo-b-hydroxy-, ethyl ester
• CAS No.: 51699-41-3
• Molecular Formula: C11H13BrO3
• Molecular Weight: 273.126
• Mol file: 51699-41-3.mol

Synonyms:ethyl 3-(m-bromophenyl)-3-hydroxypropanoate;Ethyl-3-hydroxy-3-(m-bromphenyl)propionat;(-)-ethyl 3-(3-bromophenyl)-3-hydroxypropionate;ethyl 3-(3-bromophenyl)-3-hydroxypropanoate;

Chemical Property of Benzenepropanoic acid, 3-bromo-b-hydroxy-, ethyl ester

Chemical Property:

• PSA: 46.53000
• LogP: 2.43570

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-(3-bromophenyl)-3-hydroxypropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, 3-bromo-b-hydroxy-, ethyl ester

There total 10 articles about Benzenepropanoic acid, 3-bromo-b-hydroxy-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

m-bromobenzoic aldehyde (3132-99-8) + ethyl bromoacetate (105-36-2) → ethyl 3-hydroxy-3-(3-bromophenyl)-propanoate (51699-41-3)

Guidance literature:

With indium; at 20 ℃; for 3h;

DOI:10.1055/s-2007-990799

Reference yield: 80.0%

m-bromobenzoic aldehyde (3132-99-8) + trimethylsilanyl-acetic acid ethyl ester (4071-88-9) → ethyl 3-hydroxy-3-(3-bromophenyl)-propanoate (51699-41-3)

Guidance literature:

m-bromobenzoic aldehyde; trimethylsilanyl-acetic acid ethyl ester; With 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h; Inert atmosphere; Green chemistry;

With hydrogenchloride; In water; N,N-dimethyl-formamide; for 0.5h; Inert atmosphere; Green chemistry;

DOI:10.1016/j.tet.2012.11.015

Reference yield: 78.0%

→ ethyl 3-hydroxy-3-(3-bromophenyl)-propanoate (51699-41-3)

Guidance literature:

With iodine; iron; In acetonitrile; at 60 ℃;

upstream raw materials:

m-bromobenzoic aldehyde

ethyl bromoacetate

ethyl acetate

ethyl iodoacetae

Downstream raw materials:

1-(3-bromophenyl)propane-1,3-diol

3-hydroxy-3-(3'-bromophenyl)propionic acid

3-(3-bromophenyl)isoxazol-5(4H)-one

(Z)-3-(3-bromophenyl)-4-{4-[4-(trifluoromethoxy)benzyloxy]benzylidene}isoxazol-5(4H)-one

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