4-(1H-IMIDAZOL-4-YL)-PYRIDINE

Base Information

• Chemical Name: 4-(1H-IMIDAZOL-4-YL)-PYRIDINE
• CAS No.: 51746-87-3
• Molecular Formula: C8H7N3
• Molecular Weight: 145.16100
• Hs Code.: 2933990090
• Mol file: 51746-87-3.mol

Synonyms:4-(1H-Imidazol-4-yl)pyridine;

Chemical Property of 4-(1H-IMIDAZOL-4-YL)-PYRIDINE

Chemical Property:

• Melting Point: 195-196℃ (acetone hexane )
• PSA: 41.57000
• LogP: 1.47170
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(1H-imidazol-4-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1H-IMIDAZOL-4-YL)-PYRIDINE

There total 5 articles about 4-(1H-IMIDAZOL-4-YL)-PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

→ 4-(1H-imidazol-4-yl)pyridine (51746-87-3)

Guidance literature:

Reference yield: 44.0%

4-(4-pyridyl)imidazole-2-thione hydrochloride (167897-35-0) → 4-(1H-imidazol-4-yl)pyridine (51746-87-3)

Guidance literature:

With nickel; In ethanol; for 6h; Heating;

DOI:10.1021/jm00017a018

Reference yield: 41.0%

4-iodoimidazole (71759-89-2) + 4-pyridylboronic acid (1692-15-5) → 4-(1H-imidazol-4-yl)pyridine (51746-87-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 110 ℃; for 1h; Solvent; Temperature; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.09.104

upstream raw materials:

4-(4-pyridyl)imidazole-2-thione hydrochloride

4-(α-aminoacetyl)pyridine dihydrochloride

2-(4-pyridyl)-2,2-dimethoxyethylamine dihydrochloride

4-iodoimidazole

Refernces

• 1、 -. "IMIDAZOLE DERIVATIVES AS IDO INHIBITORS". Page/Page column 120. . Retrieved 2011/06/11.
• 2、 -. "Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists". . . Retrieved 2008/06/13.