Tert-butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate

Base Information Edit

Chemical Name:Tert-butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate
CAS No.:518044-32-1
Molecular Formula:C15H30O7
Molecular Weight:322.399
Hs Code.:2918999090
European Community (EC) Number:970-420-5
Mol file:518044-32-1.mol

Synonyms:518044-32-1;TERT-BUTYL 1-HYDROXY-3,6,9,12-TETRAOXAPENTADECAN-15-OATE;Hydroxy-PEG4-t-butyl ester;Hydroxy-PEG4-t-butly ester;HO-PEG4-CH2CH2COOtBu;Hydroxy-PEG4-(CH2)2-Boc;t-Butyl 3-Hydroxy(PEG4)propoinate;Tert-butyl 3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate;C15H30O7;MFCD11041117;PEG5-Carboxylic Acid tert-Butyl Ester;OH-PEG4-TBA;OH-PEG4-CH2CH2COOtBu;HO-DPEG(4)-CO-OTBU;HO-PEG4-t-butyl ester;LCZC846;LCZC847;SCHEMBL722740;AMY4544;FJRDXEGYAVAMLB-UHFFFAOYSA-N;ZB0979;AKOS030213480;HY-W039178;s10685;AS-54494;BP-20402;SY122495;B5901;CS-0096865;EN300-305340;A901384;15-Hydroxy-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester;TERT-BUTYL1-HYDROXY-3,6,9,12-TETRAOXAPENTADECAN-15-OATE;15-HYDROXY-4,7,10,13-TETRAOXA-PENTADECANOIC ACID T-BUTYL ESTER;tert-butyl 3-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)propanoate;tert-Butyl 1-Hydroxy-3,6,9,12-tetraoxapentadecan-15-oate

Suppliers and Price of Tert-butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Hydroxy-Peg4-T-ButlyEster
500mg
$ 155.00

TCI Chemical
PEG5-Carboxylic Acid tert-Butyl Ester
1G
$ 123.00

TCI Chemical
PEG5-Carboxylic Acid tert-Butyl Ester
5G
$ 418.00

Sigma-Aldrich
Hydroxy-PEG5-t-butyl ester
1 g
$ 626.00

Sigma-Aldrich
Hydroxy-PEG4-t-butyl ester
250mg
$ 76.10

Sigma-Aldrich
Hydroxy-PEG4-t-butyl ester
1g
$ 224.00

Sigma-Aldrich
Hydroxy-PEG5-t-butyl ester
250 mg
$ 216.00

purepeg
HO-PEG4-CH2CH2COOtBu min.95%
5 g
$ 206.00

Iris Biotech GmbH
HO-dPEG(4)-CO-OtBu
1 g
$ 432.00

Iris Biotech GmbH
HO-dPEG(4)-CO-OtBu
100 mg
$ 270.00

Total 21 raw suppliers

Chemical Property of Tert-butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate Edit

Chemical Property:

Refractive Index:n/D 1.4492
Boiling Point:406.8±35.0 °C(Predicted)
PKA:14.36±0.10(Predicted)
PSA：83.45000
Density:1.04746 g/mL
LogP:0.77690
Storage Temp.:2-8°C
Solubility.:Soluble in Water, DCM
XLogP3:-0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:16
Exact Mass:322.19915329
Heavy Atom Count:22
Complexity:263

Purity/Quality:

97% ^*data from raw suppliers

Hydroxy-Peg4-T-ButlyEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)CCOCCOCCOCCOCCO
Description Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Technology Process of Tert-butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate

There total 4 articles about Tert-butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%