Tetraethylene glycol

Base Information

• Chemical Name: Tetraethylene glycol
• CAS No.: 112-60-7
• Deprecated CAS: 79688-08-7,1186024-61-2
• Molecular Formula: C8H18O5
• Molecular Weight: 194.228
• Hs Code.: 29094919
• European Community (EC) Number: 203-989-9,695-760-9,874-684-1
• NSC Number: 1262
• DSSTox Substance ID: DTXSID9026922
• Nikkaji Number: J43.377B
• Wikidata: Q12430182
• NCI Thesaurus Code: C84077
• RXCUI: 1368864
• Metabolomics Workbench ID: 56590
• ChEMBL ID: CHEMBL1235254
• Mol file: 112-60-7.mol

Synonyms:tetraethylene glycol

Chemical Property of Tetraethylene glycol

Chemical Property:

• Appearance/Colour: colorless to light yellowish liquid
• Vapor Pressure: <0.01 mm Hg
• Melting Point: -5.6 °C(lit.)
• Refractive Index: n20/D 1.459(lit.)
• Boiling Point: 328 °C at 760 mmHg
• PKA: 14.06±0.10(Predicted)
• Flash Point: 176.7 °C
• PSA: 68.15000
• Density: 1.125 g/cm³
• LogP: -0.97920
• Storage Temp.: Store below +30°C.
• Solubility.: 1000g/l
• Water Solubility.: soluble
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 194.11542367
• Heavy Atom Count: 13
• Complexity: 78.6

Purity/Quality:

98% ^*data from raw suppliers

Bis[2-(2-hydroxyethoxy)ethyl]Ether(TetraethyleneGlycol) ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Ethylene Glycols
• Canonical SMILES: C(COCCOCCOCCO)O
• Uses: Solvent for nitrocellulose, plasticizer, lacquers, coating compositions. Tetraethylene glycol is used as a solvent to dissolve water-insoluble compounds. It is employed as a nitrocellulose solvent, a plasticizer, a natural gas desiccant, a hydraulic fluid and in lacquers and coatings. Furthermore, it is used in the synthesis of tetraethylene glycol methacrylate monomer. It acts as a chemical intermediate and acts as a solvent for the manufacturing of inks and dyes. In addition, it serves as a coupling agent in the production of textile lubricants and formulations.

Technology Process of Tetraethylene glycol

There total 23 articles about Tetraethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

→ Tetraethylene glycol (112-60-7) + (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1)

Guidance literature:

Reference yield: 82.0%

→ Tetraethylene glycol (112-60-7) + tetrahydrodeoxycortisol (68-60-0)

Guidance literature:

Reference yield: 32.0%

ethylene glycol (107-21-1) + 3-oxa-1,5-dichloropentane (111-44-4) → Tetraethylene glycol (112-60-7)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 90 ℃; for 9h;

upstream raw materials:

oxirane

ethylene glycol

diethylene glycol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

tetraethylene glycol dimethacrylate

2-{2-[2-(2-hexadecyloxyethoxy)ethoxy]ethoxy}ethanol

1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol

tetraethylene glycol monomethyl ether

Refernces

• 1、 Rauterkus et al.. "". . p. 166,173,174. Retrieved 1961.
• 2、 -. "Lipid carrier". . . Retrieved 2008/06/13.
• 3、 -. "Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents". . . Retrieved 2008/06/13.