6-(PROPAN-2-YLOXY)PYRIDIN-3-AMINE

Base Information

• Chemical Name: 6-(PROPAN-2-YLOXY)PYRIDIN-3-AMINE
• CAS No.: 52025-36-2
• Molecular Formula: C8H12N2O
• Molecular Weight: 152.19400
• Mol file: 52025-36-2.mol

Synonyms:6-ISOPROPOXYPYRIDIN-3-AMINE;6-(propan-2-yloxy)pyridin-3-amine;6-ISOPROPOXY-PYRIDIN-3-YLAMINE;

Chemical Property of 6-(PROPAN-2-YLOXY)PYRIDIN-3-AMINE

Chemical Property:

• PSA: 48.14000
• LogP: 2.03220

Purity/Quality:

98%min ^*data from raw suppliers

3-Pyridinamine 6-(1-methylethoxy)-95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(PROPAN-2-YLOXY)PYRIDIN-3-AMINE

There total 2 articles about 6-(PROPAN-2-YLOXY)PYRIDIN-3-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-isopropoxy-5-nitropyridine (24903-85-3) → 6-(propan-2-yloxy)pyridin-3-amine (52025-36-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 6h;

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → 6-(propan-2-yloxy)pyridin-3-amine (52025-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / mineral oil / 2 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; mineral oil;

Reference yield: 26.0%

6-(propan-2-yloxy)pyridin-3-amine (52025-36-2) + 4-(chlorosulfonyl)benzenesulfonyl fluoride (30672-72-1) → C14H15FN2O5S2

Guidance literature:

With pyridine; In chloroform; at 20 ℃; for 48h; chemoselective reaction;

DOI:10.1021/acscombsci.8b00130

upstream raw materials:

2-isopropoxy-5-nitropyridine

2-chloro-5-nitropyridine

Refernces

• 1、 -. "INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION". Page/Page column 103. . Retrieved 2016/11/14.
• 2、 Colley, Helen E.,Muthana, Munitta,Danson, Sarah J.,Jackson, Lucinda V.,Brett, Matthew L.,Harrison, Joanne,Coole, Sean F.,Mason, Daniel P.,Jennings, Luke R.,Wong, Melanie,Tulasi, Vamshi,Norman, Dennis,Lockey, Peter M.,Williams, Lynne,Dossetter, Alexander G.,Griffen, Edward J.,Thompson, Mark J.. "An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer". . p. 9309 - 9333. Retrieved 2015/12/23.