24903-85-3

Basic information

• Product Name: 2-ISOPROPOXY-5-NITRO-PYRIDINE
• Synonyms: 2-ISOPROPOXY-5-NITRO-PYRIDINE;5-nitro-2-propan-2-yloxypyridine
• CAS NO: 24903-85-3
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.1766
• Mol File: 24903-85-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-ISOPROPOXY-5-NITRO-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ISOPROPOXY-5-NITRO-PYRIDINE(24903-85-3)
• EPA Substance Registry System: 2-ISOPROPOXY-5-NITRO-PYRIDINE(24903-85-3)

Safety Data

• Hazardous Substances Data: 24903-85-3(Hazardous Substances Data)

Upstream product

• 465529-94-6 5-nitropyridine-2-sulfonic acid 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 193902-78-2 tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate 
• 55403-34-4 1-methyl-4-(5-nitropyridin-2-yl)piperazine 
• 55403-35-5 6-(4-methyl-1-piperazinyl)-3-pyridinylamine 
• 52025-36-2 6-(propan-2-yloxy)pyridin-3-amine 

Relevant articles and documents

Substitution reactions of 5-nitropyridine-2-sulfonic acid. A new pathway to 2,5-disubstituted pyridines

We have investigated reactions of 5-nitropyridine-2-sulfonic acid and its potassium salt in which substitution of the sulfonate group by oxygen, nitrogen and halogen nucleophiles has been attempted. By this approach, 2-methoxy-(95% yield), 2-ethoxy- (97%), 2-isopropoxy- (65%), 2-amino- (92%), 2- butylamino- (76%), 2-diethylamino- (62%), 2-ethylamino- (32%), 2-benzylamino- (77%), 2-(R-1-phenylethylamino)- (71%) and 2-chloro-5-nitropyridine (87%) have been obtained. No reactions were observed with phenols or anilines. With t-BuOH, 2-hydroxy-5-nitropyridine was formed together with 2-methylpropene.