3a,7a-Dihydroxy-5a-cholanate

Base Information

Chemical Name:3a,7a-Dihydroxy-5a-cholanate
CAS No.:15357-34-3
Molecular Formula:C24H40 O4
Molecular Weight:392.579
Hs Code.:
Mol file:15357-34-3.mol

Synonyms:3a,7a-Dihydroxy-5a-cholanate;3a,7a-Dihydroxy-5a-cholanic acid;3a,7a-dihydroxy-(5a)-cholan-24-oate;3a,7a-dihydroxy-(5a)-cholan-24-oic acid

Suppliers and Price of 3a,7a-Dihydroxy-5a-cholanate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 22 raw suppliers

Chemical Property of 3a,7a-Dihydroxy-5a-cholanate

Chemical Property:

Vapor Pressure:2.98E-14mmHg at 25°C
Boiling Point:547.1°Cat760mmHg
Flash Point:298.8°C
PSA：77.76000
Density:1.128g/cm³
LogP:4.47790
XLogP3:4.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:392.29265975
Heavy Atom Count:28
Complexity:605

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
Isomeric SMILES:C[C@H](CCC(=O)O)C1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@@H]4[C@@]3(CC[C@H](C4)O)C)O)C

Technology Process of 3a,7a-Dihydroxy-5a-cholanate

There total 16 articles about 3a,7a-Dihydroxy-5a-cholanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128-13-2,474-25-9,566-24-5,15357-34-3,30627-76-0,30634-99-2,41195-65-7,51446-79-8,78919-26-3,105227-28-9
4-((3R,7R)-3,7-Dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid

Guidance literature:: aus 3α.7α-Diacetoxy-12-oxo-5β-cholanoic Saeure;

Reference yield:

: 14773-00-3
methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate

: 15357-34-3
(3α,5α,7α)-3,7-dihydroxy-cholan-24-oic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentoxide / chloroform / 4 h / 20 °C / Inert atmosphere

2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 72 h / 40 °C / Inert atmosphere

3.1: ammonia; lithium; tert-butyl alcohol / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

4.1: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

5.1: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere

5.2: 8 h / Reflux; Inert atmosphere

With hydrogenchloride; 2-iodoxybenzoic acid; phosphorus pentoxide; ammonia; lithium; potassium tri-sec-butyl-borohydride; tert-butyl alcohol; In tetrahydrofuran; methanol; chloroform; dimethyl sulfoxide; 3.1: Birch reduction;
DOI:10.1016/j.tetlet.2011.05.140