(2-Ethylbenzofuran-3-yl)(4-hydroxy-3,5-dimethylphenyl)methanone

Base Information

Chemical Name:(2-Ethylbenzofuran-3-yl)(4-hydroxy-3,5-dimethylphenyl)methanone
CAS No.:52489-58-4
Molecular Formula:C19H18O3
Molecular Weight:294.35
Hs Code.:
ChEMBL ID:CHEMBL225481
DSSTox Substance ID:DTXSID50463863
Pharos Ligand ID:LJ15PJACKL76
Wikidata:Q82288931

Synonyms:CHEMBL225481;(2-ethylbenzofuran-3-yl)(4-hydroxy-3,5-dimethylphenyl)methanone;52489-58-4;SCHEMBL1287573;DTXSID50463863;QDFXYZHYSUTYPW-UHFFFAOYSA-N;(2-ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-dimethylphenyl)methanone;BDBM50158458

Suppliers and Price of (2-Ethylbenzofuran-3-yl)(4-hydroxy-3,5-dimethylphenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (2-Ethylbenzofuran-3-yl)(4-hydroxy-3,5-dimethylphenyl)methanone

Chemical Property:

XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:294.125594432
Heavy Atom Count:22
Complexity:396

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)C)O)C

Technology Process of (2-Ethylbenzofuran-3-yl)(4-hydroxy-3,5-dimethylphenyl)methanone

There total 6 articles about (2-Ethylbenzofuran-3-yl)(4-hydroxy-3,5-dimethylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: (2-ethylbenzofuran-3-yl)(4-methoxy-3,5-dimethylphenyl)methanone

: 52489-58-4
2-n-ethyl-3-(4-hydroxy-3,5-dimethylbenzoyl)benzofuran

Guidance literature:: With sodium thioethylate; In N,N-dimethyl-formamide; at 110 ℃; for 16h;

Reference yield:

: 100-52-7
benzaldehyde

: 52489-58-4
2-n-ethyl-3-(4-hydroxy-3,5-dimethylbenzoyl)benzofuran

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 6 h / Reflux

2.1: hydrazine / water; diethylene glycol / 120 - 190 °C

2.2: 6 h / 120 - 130 °C

3.1: carbon disulfide / 0.5 h / Inert atmosphere; Cooling with ice

3.2: 19 h / 0 - 20 °C

4.1: sodium thioethylate / N,N-dimethyl-formamide / 16 h / 110 °C

With carbon disulfide; potassium carbonate; hydrazine; sodium thioethylate; In water; N,N-dimethyl-formamide; acetone; diethylene glycol;

Reference yield:

: 1646-26-0
1-(benzo[b]furan-2-yl)ethanone

: 52489-58-4
2-n-ethyl-3-(4-hydroxy-3,5-dimethylbenzoyl)benzofuran

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine / water; diethylene glycol / 120 - 190 °C

1.2: 6 h / 120 - 130 °C

2.1: carbon disulfide / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 19 h / 0 - 20 °C

3.1: sodium thioethylate / N,N-dimethyl-formamide / 16 h / 110 °C

With carbon disulfide; hydrazine; sodium thioethylate; In water; N,N-dimethyl-formamide; diethylene glycol;