1-Methoxy-3-[2-(4-methoxyphenyl)ethyl]benzene

Base Information

• Chemical Name: 1-Methoxy-3-[2-(4-methoxyphenyl)ethyl]benzene
• CAS No.: 52528-97-9
• Molecular Formula: C16H18O2
• Molecular Weight: 242.318
• ChEMBL ID: CHEMBL477915
• DSSTox Substance ID: DTXSID50565553
• Nikkaji Number: J785.346G
• Wikidata: Q82450710
• Mol file: 52528-97-9.mol

Synonyms:3,4'-Dimethoxybibenzyl;52528-97-9;1-Methoxy-3-[2-(4-methoxyphenyl)ethyl]benzene;CHEMBL477915;SCHEMBL4949653;DTXSID50565553;1-(3-methoxyphenyl)-2-(4-methoxyphenyl)-ethane

Chemical Property of 1-Methoxy-3-[2-(4-methoxyphenyl)ethyl]benzene

Chemical Property:

• Melting Point: 36-38 °C(Solv: ethanol (64-17-5))
• Boiling Point: 342.8±22.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.049±0.06 g/cm3(Predicted)
• LogP: 3.48900
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 242.130679813
• Heavy Atom Count: 18
• Complexity: 221

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CCC2=CC(=CC=C2)OC

Technology Process of 1-Methoxy-3-[2-(4-methoxyphenyl)ethyl]benzene

There total 17 articles about 1-Methoxy-3-[2-(4-methoxyphenyl)ethyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,4'-Dimethoxystilben (39032-14-9) → 1-methoxy-3-(4-methoxyphenethyl)benzene (52528-97-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2012.10.052

Reference yield:

1-bromomethyl-3-methoxybenzene (874-98-6) → 1-methoxy-3-(4-methoxyphenethyl)benzene (52528-97-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.8 g / dimethylformamide / 4 h / 160 °C

2: 430 mg / NaOEt / ethanol / Heating

3: 300 mg / hydrogen / 10percent Pd-C / ethanol

4: 75 mg

With hydrogen; sodium ethanolate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/0031-9422(82)83095-1

Reference yield:

3-methoxybenzyl alcohol (6971-51-3) → 1-methoxy-3-(4-methoxyphenethyl)benzene (52528-97-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.0 g / 47percent HBr / benzene

2: 1.8 g / dimethylformamide / 4 h / 160 °C

3: 430 mg / NaOEt / ethanol / Heating

4: 300 mg / hydrogen / 10percent Pd-C / ethanol

5: 75 mg

With hydrogen bromide; hydrogen; sodium ethanolate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; benzene;

DOI:10.1016/0031-9422(82)83095-1

upstream raw materials:

1-[(E)-2-(4-methoxyphenyl)ethenyl]-3-methoxybenzene

4-((3-methoxyphenyl)ethyl)phenol

dimethyl sulfate

3,4'-dimethoxy-deoxybenzoin

Downstream raw materials:

lunularin

3,4'-bis-benzoyloxy-bibenzyl