4-Hydroxy-3'-methoxybibenzyl

Base Information

• Chemical Name: 4-Hydroxy-3'-methoxybibenzyl
• CAS No.: 59586-27-5
• Molecular Formula: C15H16 O2
• Molecular Weight: 228.291
• Mol file: 59586-27-5.mol

Synonyms:3-Methoxy-4'-hydroxybibenzyl;4'-Hydroxy-3-methoxybibenzyl

Chemical Property of 4-Hydroxy-3'-methoxybibenzyl

Chemical Property:

• Vapor Pressure: 1.23E-05mmHg at 25°C
• Boiling Point: 358.5°C at 760 mmHg
• Flash Point: 181.6°C
• PSA: 29.46000
• Density: 1.111g/cm³
• LogP: 3.18600

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-3'-methoxybibenzyl

There total 7 articles about 4-Hydroxy-3'-methoxybibenzyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromomethyl-3-methoxybenzene (874-98-6) → 4-((3-methoxyphenyl)ethyl)phenol (59586-27-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.8 g / dimethylformamide / 4 h / 160 °C

2: 430 mg / NaOEt / ethanol / Heating

3: 300 mg / hydrogen / 10percent Pd-C / ethanol

With hydrogen; sodium ethanolate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/0031-9422(82)83095-1

Reference yield:

3-methoxy-1-iodobenzene (766-85-8) + 4-ethynylphenol (2200-91-1) → 4-((3-methoxyphenyl)ethyl)phenol (59586-27-5) + 4,4'-(butane-1,4-diyl)bisphenol (76961-97-2)

Guidance literature:

3-methoxy-1-iodobenzene; 4-ethynylphenol; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N,N-diethylnmethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

With platinum on carbon; hydrogen; for 12h; Overall yield = 99%; Overall yield = 142 mg;

DOI:10.1515/znb-2015-0047

Reference yield:

C22H20O2 (86491-57-8) → 4-((3-methoxyphenyl)ethyl)phenol (59586-27-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/0031-9422(82)83095-1

upstream raw materials:

C₂₂H₂₀O₂

3-methoxybenzyl alcohol

(3-methoxybenzyl)triphenylphosphonium bromide

1-bromomethyl-3-methoxybenzene

Downstream raw materials:

1-methoxy-3-(4-methoxyphenethyl)benzene