L-Tyrosine,O-[3-[(1,6-dihydro-6-oxo-3-pyridazinyl)methyl]-4-hydroxyphenyl]-3,5-diiodo-

Base Information

Chemical Name:L-Tyrosine,O-[3-[(1,6-dihydro-6-oxo-3-pyridazinyl)methyl]-4-hydroxyphenyl]-3,5-diiodo-
CAS No.:105170-16-9
Molecular Formula:C₂₀H₁₇I₂N₃O₅
Molecular Weight:633.181
Hs Code.:
Mol file:105170-16-9.mol

Synonyms:L 94690;L-SKF 94690; SKF-L 94690

Suppliers and Price of L-Tyrosine,O-[3-[(1,6-dihydro-6-oxo-3-pyridazinyl)methyl]-4-hydroxyphenyl]-3,5-diiodo-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Tyrosine,O-[3-[(1,6-dihydro-6-oxo-3-pyridazinyl)methyl]-4-hydroxyphenyl]-3,5-diiodo-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Tyrosine,O-[3-[(1,6-dihydro-6-oxo-3-pyridazinyl)methyl]-4-hydroxyphenyl]-3,5-diiodo-

There total 10 articles about L-Tyrosine,O-[3-[(1,6-dihydro-6-oxo-3-pyridazinyl)methyl]-4-hydroxyphenyl]-3,5-diiodo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 105170-16-9
3,5-di-iodo-3'<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-L-thyronine

Guidance literature:

Reference yield:

: 52329-05-2
5-benzyloxy-2-methoxyphenyl methanol

: 105170-16-9
3,5-di-iodo-3'<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-L-thyronine

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / phosphorus tribromide / CH₂Cl₂ / -5 °C

2: 87 percent / sodium cyanide / dimethylsulfoxide

3: 64 percent / sodium hydride / dimethylformamide / 2 h

4: 82 percent / hydrochloric acid / acetic acid; H₂O / 6 h / Heating

5: 36 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating

6: H₂ / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr

7: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h

8: 1.) boron tribromide, 2.) 2M-NaOH / 1.) methylene dichloride, 0 deg C, RT, 1.5 h, 2.) 100 deg C, 0.25 h

With hydrogenchloride; sodium cyanide; sodium hydroxide; sulfuric acid; hydrogen; iodine; boron tribromide; phosphorus tribromide; sodium hydride; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite; palladium on activated charcoal; In pyridine; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/P19880003085

Reference yield:

: 52329-06-3
5-(benzyloxy)-2-methoxybenzaldehyde

: 105170-16-9
3,5-di-iodo-3'<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-L-thyronine

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / sodium borohydride / methanol

2: 81 percent / phosphorus tribromide / CH₂Cl₂ / -5 °C

3: 87 percent / sodium cyanide / dimethylsulfoxide

4: 64 percent / sodium hydride / dimethylformamide / 2 h

5: 82 percent / hydrochloric acid / acetic acid; H₂O / 6 h / Heating

6: 36 percent / methanesulphonyl chloride / pyridine / 1.17 h / Heating

7: H₂ / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr

8: 1.) sulphuric acid, sodium nitrite, 2.) potassium iodide,iodine, urea / 1.) water, -10 deg C, 2.) chloroform, water, RT, 1-2 h

9: 1.) boron tribromide, 2.) 2M-NaOH / 1.) methylene dichloride, 0 deg C, RT, 1.5 h, 2.) 100 deg C, 0.25 h

With hydrogenchloride; sodium cyanide; sodium hydroxide; sodium tetrahydroborate; sulfuric acid; hydrogen; iodine; boron tribromide; phosphorus tribromide; sodium hydride; methanesulfonyl chloride; urea; potassium iodide; sodium nitrite; palladium on activated charcoal; In pyridine; methanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/P19880003085