52329-05-2

Upstream product

• 52329-06-3 5-(benzyloxy)-2-methoxybenzaldehyde 
• 35431-26-6 5-hydroxy-2-methoxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 84923-68-2 5-(benzyloxy)-2-methoxybenzoic acid 

Downstream Products

• 105170-17-0 5-benzyloxy-2-methoxy-benzyl bromide 
• 52329-06-3 5-(benzyloxy)-2-methoxybenzaldehyde 
• 192190-38-8 5-benzyloxy-2-methoxybenzyl chloride 
• 59907-65-2 4-methoxy-3-(methoxymethyl)phenol 
• 105170-22-7 4'-O-methyl-3,5-dinitro-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-N-trifluoroacetyl-L-thyronine ethyl ester 
• 120130-19-0 4'-O-methyl-3,5-dinitro-3'<(2-oxo-2,3-dihydrothiazol-5-yl)methyl>-N-trifluoroacetyl-L-thyronine ethyl ester 
• 105170-23-8 3,5-di-iodo-4'-O-methyl-3'-<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-N-trifluoroacetyl-L-thyronine ethyl ester 
• 120130-24-7 3,5-di-iodo-4'-O-methyl-3'-<(2-oxo-2,3-dihydrothiazol-5-yl)methyl>-N-trifluoroacetyl-L-thyronine ethyl ester 
• 105170-16-9 3,5-di-iodo-3'<(6-oxo-1,6-dihydropyridazin-3-yl)methyl>-L-thyronine 
• 105170-19-2 5-Benzyloxy-2-methoxyphenyl-(6-chloropyridazin-3-yl)-acetonitrile 
• 120130-14-5 4-benzyloxy-2-<(2-methoxythiazol-5-yl)methyl>anisole 
• 120130-27-0 5-<(5-benzyloxy-2-methoxyphenyl)methyl>thiazol-2(3H)-one 
• 120147-87-7 5-<(5-hydroxy-2-methoxyphenyl)methyl>thiazol-2-(3H)-one 
• 192190-42-4 7-Benzyloxy-1-(5-benzyloxy-2-methoxy-benzyl)-6-methoxy-2-((S)-1-phenyl-ethyl)-3,4-dihydro-isoquinolinium 

Relevant academic research and scientific papers

Design, synthesis, and structure-activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists

Herein we describe the design, synthesis, and structure-activity relationships (SARs) of a novel phenylcyclopropane series represented by 7 and 33b as antagonists of orexin 1 and orexin 2 receptors. With 4 serving as the initial lead for the development o

Synthesis of Thyroid Hormone Analogues. Part 1. Preparation of 3'-Heteroarylmethyl-3,5-di-iodo-L-thyronines via Phenol-Dinitrophenol Condensation and Relationships between Structure and Selective Thyromimetic Activity

3'-Heteroarylmethyl analogues (1)-(8) of the natural thyroid hormone 3,3',5-tri-iodo-L-thyronine (T3) were synthesized as potential selective (cardiac-sparing) thyromimetics.The diphenyl ether moiety was constructed by condensation of 3-substituted 4-methoxyphenols with a 3,5-dinitro-L-tyrosine derivative.Synthesis of the key phenols (28)-(32) required the in situ preparation, at low temperatures, of the novel metallated species 2-lithio-5-methoxypyridine (14), 5-lithio-2-methoxypyrimidine (15), 5-lithio-2-methylpyridine (16), 5-bromo-4-lithio-2-methoxypyridine (18) , and 2,6-difluoro-3-lithiopyridine (19), followed by reaction with the benzaldehyde (20).Alternative routes to the pyridazone (36) and thiazolone (37) phenols were developed from the benzyl bromide (33).Structure-activity relationships indicate that selective thyromimetic activity is associated with 2-oxyheteroaren-5-ylmethyl 3'-substitution, as found in the pyridone (1), pyridazinone (2), hydroxypyridine (4) and thiazolone (8).The location of the oxy substituent in the heterocycle is critical for both hormonal activity and for binding to the T3 receptor.

Pyridyl and pyridazinyl substituted thyronine compounds having selective thyromimetic activity

This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3''-[6-oxo-3(1H)-pyridazinylmethyl]-thyronine.