4,10-bis[(4-methylphenyl)sulfonyl]-1,7-dioxa-4,10-diazacyclododecane

Base Information

• Chemical Name: 4,10-bis[(4-methylphenyl)sulfonyl]-1,7-dioxa-4,10-diazacyclododecane
• CAS No.: 52601-77-1
• Molecular Formula: C22H30N2O6S2
• Molecular Weight: 482.622
• Mol file: 52601-77-1.mol

Synonyms:4,10-ditosyl-1,7-dioxa-4,10-diazacyclododecane;N,N'-ditosylperhydro-1,7,4,10-dioxadiazacyclododecane;N,N'-ditosyl-1,7-dioxa4,10-diazacyclododecane;4,10-bis-(toluene-4-sulfonyl)-1,7-dioxa-4,10-diaza-cyclododecane;

Chemical Property of 4,10-bis[(4-methylphenyl)sulfonyl]-1,7-dioxa-4,10-diazacyclododecane

Chemical Property:

• PSA: 109.98000
• LogP: 4.06920

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,10-bis[(4-methylphenyl)sulfonyl]-1,7-dioxa-4,10-diazacyclododecane

There total 9 articles about 4,10-bis[(4-methylphenyl)sulfonyl]-1,7-dioxa-4,10-diazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,1'-oxybis(2-bromo-ethane) (5414-19-7) + N,N'-Bis(p-tolylsulfonyl)-1,5-diamino-3-oxapentane (59945-34-5) → 4,10-bis(p-tolylsulphonyl)-1,7-dioxa-4,10-diazacyclododecane (52601-77-1)

Guidance literature:

With lithium hydroxide; tetra-(n-butyl)ammonium iodide; In toluene; for 10h; Heating;

Reference yield: 71.0%

N,N'-Bis(p-tolylsulfonyl)-1,5-diamino-3-oxapentane (59945-34-5) + diethylene glycol ditosylate (7460-82-4) → 4,10-bis(p-tolylsulphonyl)-1,7-dioxa-4,10-diazacyclododecane (52601-77-1)

Guidance literature:

With tetrabutyl-ammonium chloride; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

Reference yield: 60.0%

N,N'-Bis(p-tolylsulfonyl)-1,5-diamino-3-oxapentane (59945-34-5) + 3-oxa-1,5-dichloropentane (111-44-4) → 4,10-bis(p-tolylsulphonyl)-1,7-dioxa-4,10-diazacyclododecane (52601-77-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

DOI:10.1039/b203285f

upstream raw materials:

N,N'-Bis(p-tolylsulfonyl)-1,5-diamino-3-oxapentane

diethylene glycol ditosylate

1,1'-oxybis(2-bromo-ethane)

N,N-bis<2-<2-<(p-tolylsulfonyl)oxy>ethoxy>ethyl>-p-toluenesulfonamide

Downstream raw materials:

diaza[12]crown-4

4,10-bis<2-(p-tolylsulphonylamino)ethyl>-1,7-dioxa-4,10-diazacyclododecane

4,10-bis(p-tolylsulphonyl)-7,16,21-trioxa-1,4,10,13-tetra-azabicyclo<11.5.5>tricosane

4,13-bis(p-tolylsulphonyl)-7,10,19,24-tetraoxa-1,4,13,16-tetra-azabicyclo<14.5.5>hexacosane

Refernces

• 1、 Bosbach, Dirk,Coveney, Peter V.,Griffin, Jonathan L.W.,Putnis, Andrew,Risthaus, Peter,Stackhouse, Stephen,Whiting, Andrew. "The rational design, synthesis and demonstration of the recognition and binding of a diaza-dioxa-12-crown-4 diphosphonate macrocycle to all crystal growth faces of barium sulfate". . p. 1238 - 1245. Retrieved 2007/10/03.
• 2、 Ostaszewski, Ryszard,Jacobsson, Ulla,Jurczak, Janusz. "Efficient Synthesis of N,N'-Dimethyl Diazacoronands". . p. 221 - 228. Retrieved 2007/10/02.