Methyl 1-methyl-2,2-diphenylcyclopropanecarboxylate

Base Information

• Chemical Name: Methyl 1-methyl-2,2-diphenylcyclopropanecarboxylate
• CAS No.: 6975-21-9
• Molecular Formula: C18H18O2
• Molecular Weight: 266.34
• NSC Number: 22094
• DSSTox Substance ID: DTXSID00281599,DTXSID50864154
• ChEMBL ID: CHEMBL1595848
• Mol file: 6975-21-9.mol

Synonyms:methyl 1-methyl-2,2-diphenylcyclopropanecarboxylate;6975-21-9;NSC22094;methyl 1-methyl-2,2-diphenylcyclopropane-1-carboxylate;CBDivE_015170;MLS001173517;CHEMBL1595848;SCHEMBL12592061;DTXSID00281599;DTXSID50864154;HMS2876P12;NSC-22094;STK806421;AKOS005608125;SMR000538824;AB00076053-01;SR-01000507870;SR-01000507870-1

Chemical Property of Methyl 1-methyl-2,2-diphenylcyclopropanecarboxylate

Chemical Property:

• Vapor Pressure: 3.77E-05mmHg at 25°C
• Boiling Point: 352.7°C at 760 mmHg
• Flash Point: 160.8°C
• Density: 1.128g/cm³
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 266.130679813
• Heavy Atom Count: 20
• Complexity: 346

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1(CC1(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)OC

Technology Process of Methyl 1-methyl-2,2-diphenylcyclopropanecarboxylate

There total 6 articles about Methyl 1-methyl-2,2-diphenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

benzophenone hydrazone (5350-57-2) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → methyl 1-methyl-2,2-diphenylcyclopropanecarboxylate (6975-21-9)

Guidance literature:

With sodium methylate; In methanol; at 55 ℃; C-anode, Pt-cathode, costant current: 0.5 A, 2.3 F/mol, undivided cell;

DOI:10.1021/jo00166a006

Reference yield:

methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) + diazodiphenylmethane (908093-98-1) → methyl 1-methyl-2,2-diphenylcyclopropanecarboxylate (6975-21-9)

Guidance literature:

With Petroleum ether;

DOI:10.1021/ja01627a067

Reference yield:

1-Brom-2,2-diphenylcyclopropancarbonsaeure-methylester (13398-28-2) + methyl iodide (74-88-4) → methyl 1-methyl-2,2-diphenylcyclopropanecarboxylate (6975-21-9)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, from -78 deg C to RT;

upstream raw materials:

methacrylic acid methyl ester

diazodiphenylmethane

diazomethane

1-methyl-2,2-diphenylcyclopropanecarboxylic acid

Downstream raw materials:

<1-Methyl-2,2-diphenyl-cyclopropyl>-diphenyl-carbinol

1,1,4,4-tetraphenyl-2-methyl-1,3-butadiene

1-methyl-2,2-diphenylcyclopropanecarboxylic acid