N-(4-nitrophenyl)butanamide

Base Information

• Chemical Name: N-(4-nitrophenyl)butanamide
• CAS No.: 54191-12-7
• Molecular Formula: C10H12N2O3
• Molecular Weight: 208.217
• Hs Code.: 2924299090
• Mol file: 54191-12-7.mol

Synonyms:p-nitroanilide butyrate;Buttersaeure-<4-nitro-anilid>;

Chemical Property of N-(4-nitrophenyl)butanamide

Chemical Property:

• Vapor Pressure: 3.59E-07mmHg at 25°C
• Boiling Point: 417.3°Cat760mmHg
• Flash Point: 206.1°C
• PSA: 74.92000
• Density: 1.244g/cm³
• LogP: 2.92960

Purity/Quality:

99% ^*data from raw suppliers

N-(4-nitrophenyl)butanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-nitrophenyl)butanamide

There total 6 articles about N-(4-nitrophenyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-nitro-aniline (100-01-6,104810-17-5) + butyryl chloride (141-75-3) → N-(4'-nitrophenyl)butyramide (54191-12-7)

Guidance literature:

With NMM; In dichloromethane;

Reference yield: 80.0%

butanoic acid anhydride (106-31-0) + 4-nitro-aniline (100-01-6,104810-17-5) → N-(4'-nitrophenyl)butyramide (54191-12-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.02.013

Reference yield: 66.0%

p-nitrobenzene iodide (636-98-6) + butanamide (541-35-5) → N-(4'-nitrophenyl)butyramide (54191-12-7)

Guidance literature:

With iron(III) chloride; potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 135 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.200800293

upstream raw materials:

4-nitro-aniline

butyryl chloride

butanoic acid anhydride

p-nitrobenzene iodide

Downstream raw materials:

butyric acid-(4-amino-anilide)

1-(4'-aminophenyl)-5-propyl-1H-tetrazole

1-(4'-nitrophenyl)-5-propyl-1H-tetrazole

N-butyl-4-nitroaniline

Refernces

• 1、 Conole, Daniel,Beck, Thorsten M.,Jay-Smith, Morgan,Tingle, Malcolm D.,Eason, Charles T.,Brimble, Margaret A.,Rennison, David. "Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides". supporting information. p. 2220 - 2235. Retrieved 2014/04/17.
• 2、 Correa, Arkaitz,Elmore, Simon,Bolm, Carsten. "Iron-catalyzed N-arylations of amides". experimental part. p. 3527 - 3529. Retrieved 2009/04/11.