3-(Benzyloxy)-4-Methoxybenzonitrile

Base Information

• Chemical Name: 3-(Benzyloxy)-4-Methoxybenzonitrile
• CAS No.: 52805-37-5
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• Mol file: 52805-37-5.mol

Synonyms:

Chemical Property of 3-(Benzyloxy)-4-Methoxybenzonitrile

Chemical Property:

• Melting Point: 73-74 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 386.4±32.0 °C(Predicted)
• PSA: 42.25000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 3.14588
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-(Benzyloxy)-4-methoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Benzyloxy)-4-Methoxybenzonitrile

There total 8 articles about 3-(Benzyloxy)-4-Methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methoxy-5-cyanophenol (52805-46-6) + benzyl bromide (100-39-0) → 3-benzyloxy-4-methoxybenzonitrile (52805-37-5)

Guidance literature:

With potassium carbonate; In acetonitrile; for 1.5h; Reflux;

DOI:10.1016/j.bmcl.2017.02.059

Reference yield: 99.0%

3-Benzyloxy-4-methoxybenzoyl cyanide (97798-37-3) → 3-benzyloxy-4-methoxybenzonitrile (52805-37-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 120 ℃; for 6h;

DOI:10.1021/jo00356a029

Reference yield: 95.0%

3-benzyloxy-4-methoxybenzaldehyde oxime (55667-17-9) → 3-benzyloxy-4-methoxybenzonitrile (52805-37-5)

Guidance literature:

With phthalic anhydride; for 0.0833333h; Heating;

DOI:10.1002/jccs.200400093

upstream raw materials:

3-benzyloxy-4-methoxybenzaldehyde

3-Benzyloxy-4-methoxybenzoyl cyanide

3-benzyloxy-4-methoxybenzaldehyde oxime

(3-Benzyloxy-4-methoxy-phenyl)-hydroxy-acetonitrile

Downstream raw materials:

3-benzyloxy-4-methoxy-benzylamine

3-ethoxy-4-methoxybenzylamine

5-benzyloxy-4-methoxy-2-nitro-benzonitrile

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