Phosphonochloridic acid, methyl-, ethyl ester

Base Information

• Chemical Name: Phosphonochloridic acid, methyl-, ethyl ester
• CAS No.: 5284-09-3
• Molecular Formula: C3H8ClO2P
• Molecular Weight: 142.522
• Hs Code.: 2931900090
• Mol file: 5284-09-3.mol

Synonyms:O-ethyl chloromethylphosphonate;Ethyl methylphosphonochloridoate;O-ethyl methylchlorophosphonate;O-ethyl methylphosphonic chloride;1-(chloro-methylphosphoryl)oxyethane;ethyl methylphosphonic monochloridate;ethyl methylphosphonochloridate;Phosphonochloridic acid,methyl-,ethyl ester;Methylphosphonsaeureethylesterchlorid;

Chemical Property of Phosphonochloridic acid, methyl-, ethyl ester

Chemical Property:

• PSA: 36.11000
• LogP: 2.08460

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphonochloridic acid, methyl-, ethyl ester

There total 1 articles about Phosphonochloridic acid, methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl(1-adamantyl)methylphosphonate (79150-58-6) → ethyl methylphosphonochloridate (5284-09-3) + 1-chloroadamantane (935-56-8)

Guidance literature:

With phosphorus pentachloride; In tetrachloromethane; at 35 - 40 ℃; for 1h;

Reference yield: 91.0%

ethyl methylphosphonochloridate (5284-09-3) + (Benzylamido)phosphorsaeure-dimethylester (74124-44-0) → benzyl(dimethoxyphosphoryl)[ethoxy(methyl)phosphoryl]amine

Guidance literature:

With potassium tert-butylate; In toluene;

DOI:10.1021/acs.orglett.5b00799

Reference yield: 77.0%

ethyl methylphosphonochloridate (5284-09-3) + 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxyphenyl)propionic acid benzyl ester (82911-77-1) → Fmoc-tyrosine(O-ethyl methylphosphonate) benzyl ester (1220982-52-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0030-1258132

upstream raw materials:

ethyl(1-adamantyl)methylphosphonate

Downstream raw materials:

O-ethyl S-<2-(dimethylamino)ethyl> methylphosphonothiolate

O,S-diethyl methylphosphonothionate

O-ethylmethylthiophosphonic acid

bis