82911-77-1

Basic information

• Product Name: TyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester
• Synonyms: Fmoc-Tyr-OH;;2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxyphenyl)propionic acid benzyl ester;;N-(9-fluorenylmethyloxycarbonyl)-L-tyrosine benzyl ester;;(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxy-phenyl)-propionic acid benzyl ester;;N-(9-fluorenylmethoxycarbonyl)-L-tyrosine benzyl ester;;Nα-(fluoren-9-ylmethoxycarbonyl)-L-tyrosine benzyl ester
• CAS NO: 82911-77-1
• Molecular Formula: C31H27NO5
• Molecular Weight: 493.559
• Mol File: 82911-77-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: TyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: TyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester(82911-77-1)
• EPA Substance Registry System: TyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester(82911-77-1)

Safety Data

• Hazardous Substances Data: 82911-77-1(Hazardous Substances Data)

Usage

General Description

TyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester is a chemical compound that is commonly used in research and pharmaceutical applications. It is a derivative of tyrosine, which is an amino acid that plays a key role in protein synthesis and neurotransmitter production. The phenylmethyl ester modification of tyrosineL- helps to enhance its stability and bioavailability, making it a valuable tool in drug development and biochemical studies. TyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester has shown potential as a drug delivery system and has also been investigated for its role in cancer therapy and neurological disorders. Overall, tyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester is a versatile compound with significant potential in various biomedical applications.

Upstream product

• 71989-38-3 Fmoc-Tyr(tBu)-OH 
• 100-39-0 benzyl bromide 
• 112883-29-1 N-Fmoc-Tyr-OH 
• 100-51-6 benzyl alcohol 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 82911-72-6 dicyclohexylamine salt of N-hydroxysuccinimide 
• 24324-17-2 9-Fluorenylmethanol 
• 42406-77-9 L-tyrosine benzyl ester 

Downstream Products

• 1463469-35-3 O-(4,6-di-O-acetyl-2,3-dideoxy-α-D-arabino-hex-2-enopyranosyl)-N-(9-fluorenylmethoxycarbonyl)-L-tyrosine benzyl ester 
• 1220982-51-3 Fmoc-tyrosine(O-cyclohexyl methylphosphonate) benzyl ester 
• 1220982-50-2 Fmoc-tyrosine(O-pinacolyl methylphosphonate) benzyl ester 
• 1220982-49-9 Fmoc-tyrosine(O-isopropyl methylphosphonate) benzyl ester 
• 1220982-52-4 Fmoc-tyrosine(O-ethyl methylphosphonate) benzyl ester 

Relevant articles and documents

Synthesis aided structural determination of amyloid-β(1-15) glycopeptides, new biomarkers for Alzheimer's disease

Unique tyrosine glycosylated amyloid-β(1-15) glycopeptides were synthesized with well-defined stereochemistry at the glycosidic linkages. Aided by these glycopeptides and tandem mass spectrometry analysis, the naturally existing amyloid-β glycopeptides, isolated from Alzheimer's disease patients, were determined to contain an α-linked N-acetyl galactosamine at the modified tyrosine 10 residue. Glycosylation can significantly impact the properties of amyloid-β as the glycopeptide has much lower affinity for Cu+ ions.

Selective esterifications of primary alcohols in a water-containing solvent

Oxyma and an oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (5b), displayed a remarkable effect on selective esterifications of primary alcohols. A wide range of carboxylic acids could be esterified with primary alcohols by using EDCI, NaHCO3, and Oxyma or Oxyma derivative 5b in 5% H2O-CH3CN. Oxyma derivative 5b is particularly useful, since it could be removed after the reaction via a simple basic or an acidic aqueous workup procedure.