82911-77-1

Usage

Uses

Used in Pharmaceutical Research and Development:
TyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester is used as a research tool for its potential role in drug development due to its enhanced stability and bioavailability, facilitating the study of its interactions with biological systems and its potential therapeutic effects.
Used in Drug Delivery Systems:
In the pharmaceutical industry, TyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester is utilized as a component in drug delivery systems to improve the efficacy and targeted delivery of therapeutic agents, taking advantage of its chemical properties to enhance drug performance.
Used in Cancer Therapy Research:
TyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester is investigated for its potential application in cancer therapy, where it may contribute to the development of novel treatment strategies by targeting specific cancer-related pathways or enhancing the effectiveness of existing treatments.
Used in Neurological Disorder Research:
In the field of neurology, TyrosineL-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, phenylmethyl ester is explored for its possible role in the treatment or understanding of neurological disorders, potentially due to its influence on neurotransmitter production or other neurobiological processes related to such conditions.

Upstream product

• 42406-77-9 L-tyrosine benzyl ester 
• 112883-29-1 N-Fmoc-Tyr-OH 
• 100-51-6 benzyl alcohol 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 
• 100-39-0 benzyl bromide 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 82911-72-6 dicyclohexylamine salt of N-hydroxysuccinimide 
• 24324-17-2 9-Fluorenylmethanol 

Downstream Products

• 1220982-52-4 Fmoc-tyrosine(O-ethyl methylphosphonate) benzyl ester 
• 1220982-49-9 Fmoc-tyrosine(O-isopropyl methylphosphonate) benzyl ester 
• 1220982-50-2 Fmoc-tyrosine(O-pinacolyl methylphosphonate) benzyl ester 
• 1220982-51-3 Fmoc-tyrosine(O-cyclohexyl methylphosphonate) benzyl ester 
• 1463469-35-3 O-(4,6-di-O-acetyl-2,3-dideoxy-α-D-arabino-hex-2-enopyranosyl)-N-(9-fluorenylmethoxycarbonyl)-L-tyrosine benzyl ester 

Relevant academic research and scientific papers

Synthesis aided structural determination of amyloid-β(1-15) glycopeptides, new biomarkers for Alzheimer's disease

Unique tyrosine glycosylated amyloid-β(1-15) glycopeptides were synthesized with well-defined stereochemistry at the glycosidic linkages. Aided by these glycopeptides and tandem mass spectrometry analysis, the naturally existing amyloid-β glycopeptides, isolated from Alzheimer's disease patients, were determined to contain an α-linked N-acetyl galactosamine at the modified tyrosine 10 residue. Glycosylation can significantly impact the properties of amyloid-β as the glycopeptide has much lower affinity for Cu+ ions.

Selective esterifications of primary alcohols in a water-containing solvent

Oxyma and an oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (5b), displayed a remarkable effect on selective esterifications of primary alcohols. A wide range of carboxylic acids could be esterified with primary alcohols by using EDCI, NaHCO3, and Oxyma or Oxyma derivative 5b in 5% H2O-CH3CN. Oxyma derivative 5b is particularly useful, since it could be removed after the reaction via a simple basic or an acidic aqueous workup procedure.

Selective esterifications of primary alcohols in a water-containing solvent

Oxyma and an oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (5b), displayed a remarkable effect on selective esterifications of primary alcohols. A wide range of carboxylic acids could be esterified with primary alcohols by using EDCI, NaHCO3, and Oxyma or Oxyma derivative 5b in 5% H2O-CH3CN. Oxyma derivative 5b is particularly useful, since it could be removed after the reaction via a simple basic or an acidic aqueous workup procedure.

Introduction of 9-fluorenylmethyloxycarbonyl, trichloroethoxycarbonyl, and benzyloxycarbonyl amine protecting groups into O-unprotected hydroxyamino acids using succinimidyl carbonates

9-Fluorenylmethyl succinimidyl, pentachlorophenyl, and benzotriazole-1-yl carbonates were prepared and their reactivity with L-serine and L-serine benzyl ester was compared.The most efficient reagent, 9-fluorenylmethyl succinimidyl carbonate, was used for the preparation of 9-flourenylmethyloxycarbonyl derivatives of other hydroxyamino acids and hydroxyamino acid esters in high yields.The use of trichloroethyl and benzyl succinimidyl carbonates for an efficient conversion of hydroxyamino acids and their esters into the corresponding N-trichloroethoxycarbonyl and benzyloxycarbonyl derivatives is described.