1H-Indole-3-ethanol, 2-methyl-1-(phenylmethyl)-

Base Information

Chemical Name:1H-Indole-3-ethanol, 2-methyl-1-(phenylmethyl)-
CAS No.:52915-55-6
Molecular Formula:C18H19NO
Molecular Weight:265.355
Hs Code.:
DSSTox Substance ID:DTXSID20353525
Nikkaji Number:J2.215.521K
Wikidata:Q82131172
Mol file:52915-55-6.mol

Synonyms:2-(1-benzyl-2-methylindol-3-yl)ethanol;1H-Indole-3-ethanol, 2-methyl-1-(phenylmethyl)-;52915-55-6;Oprea1_196901;CBDivE_013286;DTXSID20353525;SR-01000195470;SR-01000195470-1

Suppliers and Price of 1H-Indole-3-ethanol, 2-methyl-1-(phenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1H-Indole-3-ethanol, 2-methyl-1-(phenylmethyl)-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:265.146664230
Heavy Atom Count:20
Complexity:300

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C2=CC=CC=C2N1CC3=CC=CC=C3)CCO

Technology Process of 1H-Indole-3-ethanol, 2-methyl-1-(phenylmethyl)-

There total 10 articles about 1H-Indole-3-ethanol, 2-methyl-1-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 5390-04-5
pent-1-yn-5-ol

: 614-31-3
N-benzyl-N-phenylhydrazine

: 52915-55-6
2-(1-benzyl-2-methyl-1H-3-indolyl)-1-ethanol

Guidance literature:: With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); toluene-4-sulfonic acid; In toluene; at 100 ℃; for 2h; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201001114

Reference yield: 80.0%

: 863889-88-7
N-benzyl-3-(2-{tert-butyldimethylsilyloxy}ethyl)-2-methyl-1H-indole

: 52915-55-6
2-(1-benzyl-2-methyl-1H-3-indolyl)-1-ethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tet.2005.05.093

Reference yield:

: N-benzyl-N'-[4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butylidene]-N-phenyl-hydrazine

: 52915-55-6
2-(1-benzyl-2-methyl-1H-3-indolyl)-1-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: ZnCl₂ / toluene / 24 h / 100 °C

2: 80 percent / TBAF*3H₂O / tetrahydrofuran / 20 °C

With tetrabutyl ammonium fluoride; zinc(II) chloride; In tetrahydrofuran; toluene; 1: Fischer indole cyclization;
DOI:10.1016/j.tet.2005.05.093