1(3H)-Isobenzofuranone,3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy- (9CI)

Base Information

• Chemical Name: 1(3H)-Isobenzofuranone,3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy- (9CI)
• CAS No.: 107584-58-7
• Molecular Formula: C18H18 O6
• Molecular Weight: 330.337
• Mol file: 107584-58-7.mol

Synonyms:Balantiolide

Chemical Property of 1(3H)-Isobenzofuranone,3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy- (9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1(3H)-Isobenzofuranone,3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy- (9CI)

There total 5 articles about 1(3H)-Isobenzofuranone,3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(Z)-3-(3,4-dimethoxybenzylidene)-7-hydroxy-5-methoxyphthalide (206130-75-8) → 3-(3,4-dimethoxybenzyl)-7-hydroxy-5-methoxyphthalide (107584-58-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; under 3620.04 Torr;

Reference yield:

5,7-dimethoxyphthalide (3465-69-8) → 3-(3,4-dimethoxybenzyl)-7-hydroxy-5-methoxyphthalide (107584-58-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, from -78 deg C to RT, 1.5 h

2: 30 percent / p-toluenesulphonic acid / benzene / Heating

3: 81 percent / AlCl₃ / CH₂Cl₂ / 2 h / Ambient temperature

4: 71 percent / H₂ / 10percent Pd/C / ethyl acetate / 3620.04 Torr

With n-butyllithium; aluminium trichloride; hydrogen; toluene-4-sulfonic acid; diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; benzene;

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → 3-(3,4-dimethoxybenzyl)-7-hydroxy-5-methoxyphthalide (107584-58-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, from -78 deg C to RT, 1.5 h

2: 30 percent / p-toluenesulphonic acid / benzene / Heating

3: 81 percent / AlCl₃ / CH₂Cl₂ / 2 h / Ambient temperature

4: 71 percent / H₂ / 10percent Pd/C / ethyl acetate / 3620.04 Torr

With n-butyllithium; aluminium trichloride; hydrogen; toluene-4-sulfonic acid; diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; benzene;

upstream raw materials:

(Z)-3-(3,4-dimethoxybenzylidene)-7-hydroxy-5-methoxyphthalide

5,7-dimethoxyphthalide

3,4-dimethoxy-benzaldehyde

(Z)-3-(3,4-dimethoxybenzylidene)-5,7-dimethoxyisobenzofuran-1(3H)-one

Refernces