3465-69-8Relevant academic research and scientific papers
Studies toward the synthesis of caramboxin analogues
Oliveira Filho, Ronaldo E.,Higa, Vanessa M.,Omori, álvaro T.
, p. 528 - 540 (2019/08/26)
Intrigued by the recent discovery of caramboxin by Brazilian researchers, we present the results from our studies toward the racemic synthesis of caramboxin analogs through the ortho-carboxylation of 3,5-dimethoxy benzyl derivatives. Three different approaches were tested, and the route involving a Vilsmeier-Haack formylation followed by a Lindgren oxidation provide a potential intermediate for the synthesis of several caramboxin analogs.
Deoxygenation of Highly Hindered Phenols
Saa, Jose M.,Dopico, Mercedes,Martorell, Gabriel,Garcia-Raso, Angel
, p. 991 - 995 (2007/10/02)
Highly hindered phenolic compounds can be efficiently deoxygenated by reduction of the corresponding triflates under homogeneous or heterogeneous (Pd/C) conditions.Reductive deoxygenation under homogeneous conditions has been shown to occur both in the presence of acid (HCOOH, CH3COOH, (CH3)3CCOOH, PhCH2COOH) or in its absence.The concomitant formation of dibutylformamide apparently derives from aminolysis of DMF by dibutylamine, the Pd(0)-catalyzed hydrolysis product of tributylamine.Deuteration experiments suggest that several hydrogen (or deuterium) sources operate in the hydrogenolysis processes studied.
