1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid

Base Information

• Chemical Name: 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid
• CAS No.: 214139-28-3
• Molecular Formula: C₂₅H₂₁NO₄
• Molecular Weight: 399.446
• Hs Code.: 29224999
• European Community (EC) Number: 874-063-5
• DSSTox Substance ID: DTXSID20369787
• Mol file: 214139-28-3.mol

Synonyms:214139-28-3;1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid;N-FMOC-DL-1-AMINOINDANE-1-CARBOXYLIC ACID;1-(FMOC-AMINO)INDANE-1-CARBOXYLIC ACID;1-(9H-fluoren-9-ylmethoxycarbonylamino)-2,3-dihydroindene-1-carboxylic Acid;MFCD01321019;1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-1-carboxylic acid;Fmoc-(R,S)-1-aminoindane-1-carboxylic acid;FMOC-DL-1-AMINOINDANE-1-CARBOXYLIC ACID;SCHEMBL20338583;1-[(fluoren-9-ylmethoxy)carbonylamino]indanecarboxylic acid;DTXSID20369787;JKVSMORCWJVCAE-UHFFFAOYSA-N;Fmoc-1-aminoindan-1-carboxylic acid;AKOS016001149;AB09043;1-(Fmoc-amino)-indan-1-carboxylic acid;AS-74095;SY014499;CS-0217665;FT-0679896;EN300-81301;F16495;A879117;N-Fmoc-DL-1-aminoindane-1-carboxylic acid, AldrichCPR;1-(((9H-fluoren-9-yl)methoxy)carbonylamino)-2,3-dihydro-1H-indene-1-carboxylic acid

Chemical Property of 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid

Chemical Property:

• Vapor Pressure: 2.43E-17mmHg at 25°C
• Melting Point: 180-185°C
• Boiling Point: 641.6°C at 760 mmHg
• Flash Point: 341.8°C
• PSA: 75.63000
• LogP: 4.84230
• Storage Temp.: Store at -15°C
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 399.14705815
• Heavy Atom Count: 30
• Complexity: 644

Purity/Quality:

98%min ^*data from raw suppliers

Fmoc-DL-1-aminoindane-1-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(C2=CC=CC=C21)(C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
• Uses: N-Fmoc-DL-1-aminoindane-1-carboxylic Acid is used to prepare inhibitors of interaction of individual nuclear hormone receptors with mutually shared steroid receptor coactivator 2.

Technology Process of 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid

There total 1 articles about 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-amino-2,3-dihydro-1H-indene-1-carboxylic acid (3927-71-7) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 1-(9H-fluoren-9-ylmethoxycarbonylamino)-indan-1-carboxylic acid (214139-28-3)

Guidance literature:

With phosphate buffer; In N,N-dimethyl-formamide; at 0 ℃; for 24h; pH=9 - 10;

DOI:10.1021/ja0348391

Reference yield:

benzo[b]thiophene-2-carboxylic acid (6314-28-9) + 3,6-dioxa-1,8-diaminooctane (929-59-9,892154-56-2) + N-Fmoc L-Phe (35661-40-6) + 1-(9H-fluoren-9-ylmethoxycarbonylamino)-indan-1-carboxylic acid (214139-28-3) → C34H38N4O5S

Guidance literature:

Multistep reaction.;

DOI:10.1016/j.bmcl.2007.06.053

Reference yield:

benzo[b]thiophene-2-carboxylic acid (6314-28-9) + Fmoc-D-Phe-OH (86123-10-6) + 3-dibutylaminopropylamine (102-83-0) + 1-(9H-fluoren-9-ylmethoxycarbonylamino)-indan-1-carboxylic acid (214139-28-3) → C39H48N4O3S

Guidance literature:

Multistep reaction.;

DOI:10.1016/j.bmcl.2007.06.053

upstream raw materials:

1-amino-2,3-dihydro-1H-indene-1-carboxylic acid

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Refernces