Phosphine, bis(1,1-dimethylethyl)(2-methoxyphenyl)-

Base Information

• Chemical Name: Phosphine, bis(1,1-dimethylethyl)(2-methoxyphenyl)-
• CAS No.: 53098-11-6
• Molecular Formula: C15H25OP
• Molecular Weight: 252.337
• Mol file: 53098-11-6.mol

Synonyms:di(tert-butyl)-2-methoxyphenylphosphine;2-Methoxyphenyl-di-t-butylphosphin;Bu(t)2P(C6H4OCH3-2);Phosphine,bis(1,1-dimethylethyl)(2-methoxyphenyl);di(t-butyl)(o-methoxyphenyl)phosphine;

Chemical Property of Phosphine, bis(1,1-dimethylethyl)(2-methoxyphenyl)-

Chemical Property:

• PSA: 22.82000
• LogP: 4.39940

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphine, bis(1,1-dimethylethyl)(2-methoxyphenyl)-

There total 3 articles about Phosphine, bis(1,1-dimethylethyl)(2-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

di(tert-butyl)chlorophosphine (13716-10-4) + 2-methoxyphenyllithium (31600-86-9) → di-tert-butyl(2-methoxyphenyl)phosphine (53098-11-6)

Guidance literature:

In diethyl ether; at 20 ℃; for 120h; Inert atmosphere;

DOI:10.1021/jacs.8b00928

Reference yield: 85.0%

di(tert-butyl)chlorophosphine (13716-10-4) + 2-bromoanisole (578-57-4) → di-tert-butyl(2-methoxyphenyl)phosphine (53098-11-6)

Guidance literature:

2-bromoanisole; With n-butyllithium; In diethyl ether; hexane; at 0 ℃; for 2h;

di(tert-butyl)chlorophosphine; In diethyl ether; hexane; at 0 - 20 ℃;

DOI:10.1002/anie.200502606

Reference yield:

2-bromoanisole (578-57-4) → di-tert-butyl(2-methoxyphenyl)phosphine (53098-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / pentane; hexane / 1 h / 0 - 20 °C / Inert atmosphere

2: diethyl ether / 12 h / 20 °C / Inert atmosphere; Glovebox

With n-butyllithium; In diethyl ether; hexane; pentane;

DOI:10.1021/jacs.6b10220

upstream raw materials:

di(tert-butyl)chlorophosphine

2-bromoanisole

2-methoxyphenyllithium

Downstream raw materials:

di-tert-butyl-(2-hydroxyphenyl)phosphane