Lithium, (2-methoxyphenyl)-

Base Information

• Chemical Name: Lithium, (2-methoxyphenyl)-
• CAS No.: 31600-86-9
• Molecular Formula: C7H7LiO
• Molecular Weight: 114.073
• DSSTox Substance ID: DTXSID40453697
• Mol file: 31600-86-9.mol

Synonyms:Lithium, (2-methoxyphenyl)-;2-methoxyphenyl lithium;lithioanisole;o-lithioanisole;2-lithioanisole;2-lithioanisol;31600-86-9;SCHEMBL693497;DTXSID40453697;ZWUJWCXORHCTCK-UHFFFAOYSA-N

Chemical Property of Lithium, (2-methoxyphenyl)-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 114.06569328
• Heavy Atom Count: 9
• Complexity: 156

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [Li+].COC1=CC=CC=[C-]1

Technology Process of Lithium, (2-methoxyphenyl)-

There total 17 articles about Lithium, (2-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromoanisole (578-57-4) → 2-methoxyphenyllithium (31600-86-9)

Guidance literature:

With n-butyllithium; In hexane; pentane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jacs.6b10220

Reference yield: 85.0%

n-butyllithium (109-72-8,29786-93-4) + 2-bromoanisole (578-57-4) → 2-methoxyphenyllithium (31600-86-9)

Guidance literature:

In hexane; pentane; Ambient temperature;

DOI:10.1016/0022-328X(89)85326-4

Reference yield: 85.0%

methoxybenzene (100-66-3) → 2-methoxyphenyllithium (31600-86-9)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In cyclohexane; at 60 ℃; for 18 - 24h; Reagent/catalyst; Temperature; Solvent; Time; Inert atmosphere;

DOI:10.1021/om301120e

upstream raw materials:

n-butyllithium

diethyl ether

α,α,α-trifluorotoluene

methoxybenzene

Downstream raw materials:

2-(2-methoxy-phenyl)-pyridine

2-(2-methoxyphenyl)quinoline

2-(2-methoxy-phenyl)-1,2-dihydro-quinoline

1-{2-hydroxy-phenyl}-isoquinoline

Refernces

• 1、 Harder, Sjoerd,Boersma, Jaap,Brandsma, Lambert,Mier, Guido P. M. van,Kanters, Jan A.. "The molecular structure of 1-lithio-2-methoxybenzene in the solid state and in solution". . p. 1 - 16. Retrieved 1989.
• 2、 Slocum,Reed,Jackson III,Friesen. "Media effects in directed ortho metalation". . p. 265 - 267. Retrieved 1996.
• 3、 Elemans, Johannes A. A. W.,Klop, Jo?lle-Rose,Mabesoone, Mathijs F. J.,Meijer, Eline M.,Nolte, Roeland J. M.,Peters, Theo P. J.,Rowan, Alan E.,Stout, Kathleen,Visschers, Fabian L. L.,White, Paul B.,van den Berg, Jeroen. "Double Porphyrin Cage Compounds". . p. 7087 - 7100. Retrieved 2020/12/07.
• 4、 Minami, Yasunori,Noguchi, Yuta,Hiyama, Tamejiro. "Synthesis of Benzosiloles by Intramolecular anti-Hydroarylation via ortho-C-H Activation of Aryloxyethynyl Silanes". supporting information. p. 14013 - 14016. Retrieved 2017/10/17.