N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide

Base Information

Chemical Name:N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide
CAS No.:53101-17-0
Molecular Formula:C12H12N2OS
Molecular Weight:232.30100
Hs Code.:
DSSTox Substance ID:DTXSID20350675
Wikidata:Q82126740
Mol file:53101-17-0.mol

Synonyms:N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide;53101-17-0;N-(4-(p-tolyl)thiazol-2-yl)acetamide;Acetamide, N-[4-(4-methylphenyl)-2-thiazolyl]-;DTXSID20350675;STK697316;2-acetamido-4-p-tolyl-1,3-thiazole;AKOS000651095;SR-01000418180;SR-01000418180-1;Z27854374;F0777-0321

Suppliers and Price of N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide

Chemical Property:

PSA：73.72000
LogP:3.72640
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:232.06703418
Heavy Atom Count:16
Complexity:251

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C

Technology Process of N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide

There total 7 articles about N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2103-91-5
2-amino-4-(p-methylphenyl)-1,3-thiazole

: 108-24-7
acetic anhydride

: 53101-17-0
2-(N-acetamino)-4-(4-methylphenyl)thiazole

Guidance literature:: With pyridine; aluminum oxide; at 97 - 100 ℃; for 2h; microwave irradiation;
DOI:10.1016/S0040-4039(02)00732-3

Reference yield:

: 2103-91-5
2-amino-4-(p-methylphenyl)-1,3-thiazole

: 75-36-5
acetyl chloride

: 53101-17-0
2-(N-acetamino)-4-(4-methylphenyl)thiazole

Guidance literature:: In acetic acid; for 5h; Reflux;

Reference yield:

: 122-00-9
para-methylacetophenone

: 53101-17-0
2-(N-acetamino)-4-(4-methylphenyl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: iodine / 0.17 h / 140 °C / Microwave irradiation

2: iodine / 1 h / 60 °C / Microwave irradiation

With iodine;
DOI:10.1515/chem-2015-0127